CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014927
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Single Ig IL-1-related receptor 
Protein Synonyms/Alias
 Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8; TIR8 
Gene Name
 SIGIRR 
Gene Synonyms/Alias
 UNQ301/PRO342 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
196LERRRGYKLFLDDRDubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. 
Sequence Annotation
 DOMAIN 9 109 Ig-like C2-type.
 DOMAIN 163 310 TIR.
 MOD_RES 380 380 Phosphoserine (By similarity).
 CARBOHYD 31 31 N-linked (GlcNAc...) (Potential).
 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
 CARBOHYD 102 102 N-linked (GlcNAc...) (Potential).
 DISULFID 32 98 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 410 AA 
Protein Sequence
MPGVCDRAPD FLSPSEDQVL RPALGSSVAL NCTAWVVSGP HCSLPSVQWL KDGLPLGIGG 60
HYSLHEYSWV KANLSEVLVS SVLGVNVTST EVYGAFTCSI QNISFSSFTL QRAGPTSHVA 120
AVLASLLVLL ALLLAALLYV KCRLNVLLWY QDAYGEVEIN DGKLYDAYVS YSDCPEDRKF 180
VNFILKPQLE RRRGYKLFLD DRDLLPRAEP SADLLVNLSR CRRLIVVLSD AFLSRAWCSH 240
SFREGLCRLL ELTRRPIFIT FEGQRRDPAH PALRLLRQHR HLVTLLLWRP GSVTPSSDFW 300
KEVQLALPRK VQYRPVEGDP QTQLQDDKDP MLILRGRVPE GRALDSEVDP DPEGDLGVRG 360
PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD FYCLVSKDDM 410 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IMP:HGNC.
 GO:0006953; P:acute-phase response; ISS:HGNC.
 GO:0045079; P:negative regulation of chemokine biosynthetic process; ISS:HGNC.
 GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; ISS:HGNC.
 GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; TAS:HGNC.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:HGNC.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR015621; IL1-receptor_fam.
 IPR000157; TIR_dom. 
Pfam
 PF01582; TIR 
SMART
  
PROSITE
 PS50835; IG_LIKE
 PS50104; TIR 
PRINTS