CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038497
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Ahnak 
Protein Synonyms/Alias
  
Gene Name
 Ahnak 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
272KGLDLGGKGGIRVPGacetylation[1]
503TPEMIIQKPKISMQDacetylation[2, 3]
543KGPQMAVKGSRVDIEacetylation[1]
590NVAAPKGKGGVDVILacetylation[1]
590NVAAPKGKGGVDVILsuccinylation[1]
680NMEGLGGKLKGPDINacetylation[1, 3]
731EGELKGSKVDIDTPQacetylation[1]
755IPKMKMPKFSVPGFKacetylation[1]
762KFSVPGFKAEGPEVDacetylation[1, 3]
799SIEGSEGKLKGHKFKacetylation[1, 3]
816EMNIRAPKISMPDVDacetylation[1]
816EMNIRAPKISMPDVDsuccinylation[1]
857DVELKSAKLDIDVPNacetylation[1]
883MPKIKMPKFGMPGFKacetylation[1]
927NIEGPEGKLKGPKLKacetylation[1]
941KMPEMNIKAPKISMPacetylation[1, 2]
941KMPEMNIKAPKISMPsuccinylation[1]
1004MPKIKMPKFSMPSLKacetylation[2]
1048NLEGPEGKLKGPKFKacetylation[3]
1055KLKGPKFKMPEMHFKacetylation[2]
1062KMPEMHFKAPKVSLPacetylation[2]
1076PDVDLDLKGPKMKGNacetylation[3]
1132MPKMKMPKFSMPTLKacetylation[2]
1176SLEGPEGKLKGPKFKacetylation[1]
1183KLKGPKFKMPDMHFKacetylation[2]
1183KLKGPKFKMPDMHFKubiquitination[4]
1209NMKGPKVKGDMDVTVacetylation[1]
1224PKIEGEMKVPDVDIKacetylation[2]
1260MPKMKMPKFSMPGFKacetylation[1, 2]
1260MPKMKMPKFSMPGFKsuccinylation[1]
1260MPKMKMPKFSMPGFKubiquitination[4]
1302NIEGPDAKLKGPKFKacetylation[1, 3]
1309KLKGPKFKMPEMNIKacetylation[1]
1309KLKGPKFKMPEMNIKsuccinylation[1]
1316KMPEMNIKAPKISMPubiquitination[4]
1328SMPDLHLKGPKVKGDacetylation[2, 3]
1328SMPDLHLKGPKVKGDubiquitination[4]
1391KFSMPGFKAEGPEVDacetylation[1, 2, 3]
1428SIEGPEGKLKGPKFKacetylation[1]
1461NIKGPKGKADVDASLacetylation[1]
1519KFSMPGFKGEGPEVDacetylation[1, 2]
1612AVDIKGPKVEAPDVEacetylation[1]
1680NIEGPEGKLKGPKFKacetylation[1, 3]
1775PDVDLHLKGPKVKGDacetylation[3]
1775PDVDLHLKGPKVKGDubiquitination[4]
1949DLECPDAKLKGPKFKacetylation[1]
2016DLECPDAKLKGPKFKacetylation[3]
2116HLKGPKVKGDVDVTVacetylation[1]
2116HLKGPKVKGDVDVTVsuccinylation[1]
2333KGPELDLKGPKLDANacetylation[2]
2352AVEGPEGKWKSPKFKacetylation[1]
2352AVEGPEGKWKSPKFKubiquitination[4]
2564EMNIKAPKISMPDIDubiquitination[4]
2575PDIDLNLKGPKVKGDacetylation[1, 3]
2575PDIDLNLKGPKVKGDubiquitination[4]
2595PKVEGEIKVPEVDIKubiquitination[4]
2602KVPEVDIKGPKVDIDubiquitination[4]
2605EVDIKGPKVDIDVPDacetylation[1]
2721PKVEGDLKGPDVDIKacetylation[1]
2892KFSMPGFKGEGPEVDacetylation[1, 2, 3]
2892KFSMPGFKGEGPEVDubiquitination[4]
2987SLDIKSPKLDVNAPDacetylation[1]
2987SLDIKSPKLDVNAPDsuccinylation[1]
3003DVHGPEGKLKGPKLKacetylation[1]
3091KFNFSGSKVQTPEVDubiquitination[4]
3209MPKMKMPKFGVSGIKacetylation[1]
3344KFSMPGFKGEGPEVDacetylation[1, 3, 5]
3937PKVEGDLKGPEVDIKacetylation[1, 3]
3944KGPEVDIKGPKMDISubiquitination[4]
4017NIEGPEGKLKGPKFKacetylation[1]
4024KLKGPKFKMPDLHLKacetylation[2]
4031KMPDLHLKAPKISMPacetylation[2]
4226KLKGPKFKMPDMHIKacetylation[2]
4233KMPDMHIKAPKISMPacetylation[2]
4330EGDLKGPKVDIKGPKacetylation[5]
4337KVDIKGPKLDIDTPDacetylation[1]
4353DIHGPEGKLKGPKFKacetylation[1]
4381PEVDLNLKGPKVKGDacetylation[5]
4381PEVDLNLKGPKVKGDubiquitination[4]
4651AFDGSVPKIEGTLKGacetylation[1]
4676DFEGPDAKLSGPNLKubiquitination[4]
4883DIKSPKFKAEAPLPSacetylation[1]
4961NIEGPEAKIKAPSFSubiquitination[4]
5015EGKIKFPKFSLPKISacetylation[2]
5242NLEGPKVKGSLGAAGubiquitination[4]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5656 AA 
Protein Sequence
MEKEEETTRE LLLPNWQGSG SHGLTIAQRD DGVFVQEVMQ NSPAARTGVV KEGDQIVGAT 60
IYFDNLQSGE VTQLLNTMGH HTVGLKLHRK GDRSPEPGQT WTHEVFSSRS SEVVLSGDDE 120
DYQRIYTTKI KPRLRSEDGV EGDLGETQSR TITVTRRVTA YTVDVTGREG VKDIDITSPE 180
FMIKIPRHEV TEISNTDVET QPGKTVIRLP SGSGPASPTT GSAVDIRAGA ISASGPELEG 240
AGHSKFQVTV PGAKVGSLDV NVKAKGLDLG GKGGIRVPGV DVSSSLGAGS VEVQAPSLQS 300
GDIGKIKIPT MKVPKFGVSA GLDGQIPEVG LSVSAPESSV GHKGDKPGLA IGGNIQAPHL 360
EVNPSSVNIE GLEGKLKGPQ ITGPSLEGDL GLKGTKLQGN IGMDACASKI EGSITGPSVE 420
IGTPDVDVHG LGGKLNMPKM KVPKFSASGS KGEGIGLDVA LPTGEVTLPG VSGDVSLPEI 480
ATGGLEGKMK GAKVKTPEMI IQKPKISMQD VDLSLGSCKL KGNMKTSAPE VKGDVKGPQM 540
AVKGSRVDIE TPNLEGTLTG PKISSPSGKI GACRISMADV DLNVAAPKGK GGVDVILPNV 600
EGKAKGLEVD VKGPKMDISA PDVEVHGPEW NLKMPKFSVP GVKGEGLDVN VTLPEGDISI 660
SGPKVNVEAP NVNMEGLGGK LKGPDINLPE VSVKTPKISM PDVDLHIKGP KVKGEYEVTP 720
PKLEGELKGS KVDIDTPQVD VHGPDLKIPK MKMPKFSVPG FKAEGPEVDV NLPKADLDIS 780
GTKVEVSAPD VSIEGSEGKL KGHKFKMPEM NIRAPKISMP DVDLHLKGPN VKGEYDVTVP 840
RAEGEIKVPD VELKSAKLDI DVPNVDVQGP ELHMKMPKIK MPKFGMPGFK AESPEMEVNL 900
PKSDIDVSGP NVDVKVPDVN IEGPEGKLKG PKLKMPEMNI KAPKISMPDV DLHMKGPKVK 960
GEYDVTMPKL EGDLKGPKVD VSVPDVDVHG PDWNLKMPKI KMPKFSMPSL KGEGPELDVN 1020
MPKADVDISV PKLDISAPDL NLEGPEGKLK GPKFKMPEMH FKAPKVSLPD VDLDLKGPKM 1080
KGNLDMSAPK IEGEMKAPDV DIKGPNVDIK APEVDVQGPE WSLKMPKMKM PKFSMPTLKG 1140
EGPDVDVSLP KATIDVSGPK LDIETSDVSL EGPEGKLKGP KFKMPDMHFK APKISMPDVD 1200
LNMKGPKVKG DMDVTVPKIE GEMKVPDVDI KGPKVDISAP DVDVQGPDWH LKMPKMKMPK 1260
FSMPGFKAEG PEVSLPKADL DVSGPKVDID VPDVNIEGPD AKLKGPKFKM PEMNIKAPKI 1320
SMPDLHLKGP KVKGDVDVSL PKVEGDLKGP DIDIKGPKMD INAPDMDVQG PDWHLKMPKM 1380
KMPKFSMPGF KAEGPEVDVN LPKADIDVSG PKVDIEAPDV SIEGPEGKLK GPKFKMPDMH 1440
FKAPKISMPD VDLNIKGPKG KADVDASLPE VEGGVKVPDV DIKGPKVGID APDVEVHGPD 1500
WHLKMPKVKM PKFSMPGFKG EGPEVDIPKA NIDVSGPKVD IDVPDVNIEG PDTKLKGPKF 1560
KMPEMNIKPQ KISMPDVSLN LKGPKVKADC DVSVPKVGGE IKAPAVDIKG PKVEAPDVEV 1620
HGPDWHLKMP KVKMPKFSMP GFKGEGAEVD VNLQKANIDV SGPKVDIDVP DVNIEGPEGK 1680
LKGPKFKMPS MNIQTHKISM PDVGLNLKGP KLKSGVDVSL PKVEGELKGP EVDVDVGDID 1740
IECPEGKLKG PKFKMPDMHF KTPKISMPDV DLHLKGPKVK GDMDVTMPKI EGEMKVPDVD 1800
IKGPKVDINA PDVDVRGPDW HLKMPKVKMP KFSMPGFKAE GPEVDVNLPK ADIDVSGPKV 1860
DIDVPDLDIE GPEGKLKGSK FKMPKLNIKA AKISMPDVDL NFKGPKLKGE IDASVPEMEA 1920
DLRGPQVDIK GTNVDVKVPD VDLECPDAKL KGPKFKMPDM HFKAPKISMP DVDLHLKGPK 1980
VKGDMDVTVP KLEGELKGPS VDVEVPDVDL ECPDAKLKGP KFKMPDMHFK APKISMPDVD 2040
LHLKGPKVKG DMDVTVPKLE GELKGPSVDV EVPDVDLECP DAKLKGPKFK MPDMHFKAPK 2100
ISMPDVDLHL KGPKVKGDVD VTVPKLEGEL KGPSVDVEVP DVDLECPDAK LKGPKFKMPD 2160
MHFKAPKISM PDVDLHLKGP KVKGDMDVTV PKIEGEMKVP DVDIKGPKVD INAPDVDVRG 2220
PDWHLKMPKM KMPKFSMPGF KAEGPEVDVN LPKADIDVSG PKVDIDVPDV NIEGPEGKLK 2280
GPKFKMPDMH FKAPKISMPD VDFNLKGPKI KGDIDVSVPK IEGELKGPEL DLKGPKLDAN 2340
IPEVAVEGPE GKWKSPKFKM PDMHFKTPKI SMPDIDLHLK SPKIKGEVDV DVPKLEGDLK 2400
GPNVDMSRPD IEIEGPEGKL KGPKFKMPEM NIKAPKISMP DFDLHLKGPK VKGDVDISLP 2460
KVEGDIKGPE VDIKGPKVDI NAPDVDVQGP DWHLKMPKMK MPKFSMPGFK AEGPEVDVNL 2520
PKADIDVSGP KVDIDVPDVN IEGPDAKLKG PKFKMPEMNI KAPKISMPDI DLNLKGPKVK 2580
GDVDVSLPKV EGEIKVPEVD IKGPKVDIDV PDVDVHGPDW HLKMPKIKMP KFSMPGFKGE 2640
GPEVDVSLPN ADLDVSGPKV DIDVPDVNIE GPDAKLKGPK FKMPEMNIKA PKISMPDLHL 2700
KGPKVKGDVD VSLPKVEGDL KGPDVDIKGP KMDINAPDMD VQGPDWHLKM PKMKMPKFSM 2760
PGFKAEGPEV DVNLPKADLD VSGPKVDIDV PDVNIEGPDA KLKGPKFKMP EMNIKAPKIS 2820
MPDIDLNLKG PKVKGDVDMS LPKVEGEIKV PEVDIKGPKV DIDVPDVDVH GPDWHLKMPK 2880
VKMPKFSMPG FKGEGPEVDV NLPKADLDVS GPKVDIDVPD VNIEGPDAKL KGPKFKMPEV 2940
NIKAPKISMP DLNLNLKGPN VKGDVDVSIP NIEGDLKGPS LDIKSPKLDV NAPDIDVHGP 3000
EGKLKGPKLK MPDMHVSMPK ISMPEIDLNL KGSKVKGDVD ISGPKLEGDI KVPRVDLKGP 3060
EVDISAPKVN IDGKAKKSRF KLPKFNFSGS KVQTPEVDVK LKKPDVDITA PKVDINAPEV 3120
EVQGKVKGSK FKMPFLSISS PKVSMPDVEL NLKGPKVKGD LDAAGPNLEG DFKGPKVDIK 3180
APDVQLNAPD VDVHGPEWNL KMPKMKMPKF GVSGIKAEGP DVAVDLPKGD INIEGPSMNI 3240
EGPELNVECP EGSLKGPKFK MPEMNIKAPK ISMPDIDLNL KGPKVKGDVD VSLPKVEGEI 3300
KVPEVDIKGP KVDIDVPDVD VHGPDWHLKM PKVKMPKFSM PGFKGEGPEV DVSLPKANID 3360
VSGPKVDIDV PDVNIEGPDA KLKGPKFKMP EMNIKAPKIS MPDIDLNLKG PKVKGDVDVS 3420
LPKVEGEIKV PEVDIKGPKV DIDVPDVDVH GPDWHLKMPK IKMPKFSMPG FKGEGPEVDV 3480
SLPKADLDVS GPKVDIDVPD VNIEGPDAKL KGPKFKMPEM NIKAPKISMP DIDLNLKGPK 3540
VKGDVDVSLP KVEGEIKVPE VDIKDPKVDI DVPDVDVHGP DWHLKMPKIK MPKFSMPGFK 3600
GEGPEVDVNL PKADLDVSGP KVDIDVPDVN IEGPDAKLKG PKFKMPEMNI KAPKISMPDL 3660
HLKGPKVKGD VDVSLPKVEG DLKGPDVDIK GPKMDINAPD MDVQGPDWHL KMPKMKMPKF 3720
SMPGFKAEGP EVDVNLPKVD LDVSGPKVDI DVPDVNIEGP DAKLKGPKFK MPEMNIKAPK 3780
ISMPDIDLNL KGPKVKGDVD MSLPKVEGEI KVPEVDIKGP KVDIDVPDVD VHGPDWHLKM 3840
PKVKMPKFSM PGFKGEGPEV DVNLPKADLD VSGPKVDIDV PDVNIEGPDA KLKGPKFKMP 3900
EMNIKAPKIS MPDLHLKGPK VKGDVDVSLP KVEGDLKGPE VDIKGPKMDI SAPDVDVHGP 3960
DWHLKMPKVK MPKFSMPGFK GEGPEVDVNL PKADLDVSGP KVDIEGPNVN IEGPEGKLKG 4020
PKFKMPDLHL KAPKISMPEI DLNLKGPKLK GDVDVSLPKV EGDLKGPEVD IKGPKVDISA 4080
PDMDVHGPDW HLKMPKMKMP KFSMPGFKAE GPEVDVNLPK ADIDVSGPKV DIDVPDVNIE 4140
GPDAKLKGPK FKMPEMNIKA PKISMPDFDL HLKGPKVKGD VDASLPKMEG ELKGPGIDIK 4200
CPTVDIDTPD VNIEVPEGKL KGPKFKMPDM HIKAPKISMP DFDLNLKGPK VKGDVDLALP 4260
NVEGDLKGPE IDIEGPEGKL KGPKFKVPDV QFKTPQISMS DIDLNVKGPK IKGDLDISIP 4320
KPEGDLKGPK VDIKGPKLDI DTPDIDIHGP EGKLKGPKFK MPDLHLKAPK ISMPEVDLNL 4380
KGPKVKGDVD VSLPKVEGDL KGPEVDIKGP KVDISAPDVD VHGPDWHLKM PKVKMPKFSM 4440
PGFKGEGPEV DVSLPKANID VSGPKVDIDV PDVNIEGPDA KLKGPKFKMP EMNIKAPKIS 4500
MPDIDLNLKG PKVKGDVDVS LPKVEGEIKV PEVDIKGPKV DIDVPDVDVH GPDWHLKMPK 4560
VKMPKFSMPG FKGEGPEVDV NLPKADLDVS GPKVDIDVPD VNVEGPDMKV KGPKFRMPEI 4620
NIKAPKISMP DVDLELKGPK VKGAFDGSVP KIEGTLKGPE IDMKGPGLDF EGPDAKLSGP 4680
NLKMPSLEVS VPKITGPDAN VHLKTPKVGI SAPKLGGGEV DLKGPKVDLE TPSLDVHMES 4740
PDINIEGPDV KVPKFKKPKF GFGAKSPKAD IKTPTVDVTV PEAELNVDSP EINIGGKSKK 4800
SKFKMPKIHM SGPKVKAKKQ GFDLNIPGGE IDTSLKAPDV DVSVAGPDAA LKAEVKSPKV 4860
KKTMFGKMYF PDVEFDIKSP KFKAEAPLPS PKLEGEIKVP DVDISSPGIN VEAPDIHMKA 4920
PKFKVPGVEA SGPKIEGNLK GPKVQANLDT PDINIEGPEA KIKAPSFSVS APQVSIPDVN 4980
VNLKGPKIKG DVPSVGLEGP NIDLQGPEGK IKFPKFSLPK ISAPGVKMEG GSTEIGAQMP 5040
SLEGGLSTSD MKLEGPHLSL KGPGVDLPSV DLSMPKVSGP DLDMNLKGPS LKGDLGASSP 5100
SMKLHAPGLD LKGVGGKVHI GADGVKMSGI DATTALSVGA PDVTLKGPSL QGDLAVSGDI 5160
KCPKVSVATP DVSLEASEGA VKLPHMKLPQ FGISTPGSDL DINIKGPQVC GELKGSGMDV 5220
NLKGPQISAP SMDFNLEGPK VKGSLGAAGE LKGPAIGGAL PGISIQGPEG NLQMPGIKAS 5280
GCDVKLSSGQ ISGPEIKGDL KGSGLGLHGA VPDIGVKGPS FNVASPESDF GVSLKGPKVK 5340
GGVDVSGGVS VPDINLGEGH MSVKGSGVEW KGPQVSSSLN LDTSKLAGNL HFSGPKIEGD 5400
VKGGQTGLQG PGLSVSGPQG HLESESGKVT FPKMKIPKFT FSGRELIGRE VGVDVNFPKV 5460
EANVQAGAGE GKWEESEVKL KKSKIKMPKH IFSKSKGKGG VTGSPEASIS GSKGDLKSSK 5520
ASLGSLEGEV EAEASSPKGK FSLFKSKKPR HRSNSFSDER EFSAPSTPTG TLEFAGGDAK 5580
GKHGKLKFGT FGGLGSKSKG HYEVTGSDDE AGKLQGSGVS LASKKSRLSS SSSNDSGTKV 5640
GIQLPEVELS VSTKKE 5656 
Gene Ontology
 GO:0005911; C:cell-cell junction; ISS:MGI. 
Interpro
 IPR002068; a-crystallin/Hsp20_dom.
 IPR001478; PDZ. 
Pfam
 PF00595; PDZ 
SMART
 SM00228; PDZ 
PROSITE
 PS01031; HSP20
 PS50106; PDZ 
PRINTS