CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040004
UniProt Accession
Genbank Protein ID
 Z98885 
Genbank Nucleotide ID
  
Protein Name
 Bromodomain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 BRD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
565APKCGRGKPALVRRHacetylation[1]
591IENGNYAKAARIAAEacetylation[1, 2]
669IGEHMQTKSDEKLFLacetylation[1, 2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 746 AA 
Protein Sequence
MKMEPVKELT GGGTTFSVRK TAYCDVHTPP GCTRRPLNIY GDVEMKNGVC RKESSVKTVR 60
STSKVRKKAK KAKKALAEPC AVLPTVCAPY IPPQRFIRMQ SRKCLKRDCD QQADGLCRFG 120
SFDCFRSSRR SSSTTRAWTS ASRTRTSDRL NRIANQVAIQ RKKQFVERAH SYWLLKRLSR 180
NGAPLLRRLQ SSLQSQRSSQ QRENDEEMKA AKEKLKYWQR LRHDLERARL LIELLRKREK 240
LKREQVKVEQ VAMELRLTPL TVLLRSVLDQ LQDKDPARIF AQPVPDYLDH IKHPMDFATM 300
RKRLEAQGYK NLHEFEEDFD LIIDNCMKYN ARDTVFYRAA VRLRDQGGVV LRQARREVDS 360
IGLEEASGMH LPERPAAAPR RPFSWEDVDR LLDPANRAHL GLEEQLRELL DMLDLTCAMK 420
SSGSRSKRAK LLKKEIALLR NKLSQQHSQP LPTGPGLEGF EEDGAALGPE AGEEVLPRLE 480
TLLQPRKRSR STCGDSEVEE ESPGKRLDAG LTNGFGGARS EQEPGGGLGR KATPRRRCAS 540
ESSISSSNSP LCDSSFNAPK CGRGKPALVR RHTLEDRSEL ISCIENGNYA KAARIAAEVG 600
QSSMWISTDA AASVLEPLKV VWAKCSGYPS YPALIIDPKM PRVPGHHNGV TIPAPPLDVL 660
KIGEHMQTKS DEKLFLVLFF DNKRSWQWLP KSKMVPLGID ETIDKLKMME GRNSSIRKAV 720
RIAFDRAMNH LSRVHGEPTS DLSDID 746 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR000313; PWWP. 
Pfam
 PF00439; Bromodomain
 PF00855; PWWP 
SMART
 SM00297; BROMO
 SM00293; PWWP 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50812; PWWP 
PRINTS
 PR00503; BROMODOMAIN.