UniProt Accession

 GFRP_MOUSE; P99025; Q8BH29 

Genbank Protein ID

 AK028116; AK028122 

Genbank Nucleotide ID

 BAC25756.1; BAC25761.1 

Protein Name

 GTP cyclohydrolase 1 feedback regulatory protein 

Protein Synonyms/Alias

 GFRP; GTP cyclohydrolase I feedback regulatory protein; p35 

Gene Name

 Gchfr 

Gene Synonyms/Alias

 Gfrp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
36	MQHLGASKRSVLGNN	ubiquitination	[1]
59	PPRIVLDKLECKGFR	acetylation	[2, 3]
59	PPRIVLDKLECKGFR	ubiquitination	[1]
63	VLDKLECKGFRVLSM	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 84 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0042470; C:melanosome; IEA:Compara.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016597; F:amino acid binding; IEA:Compara.
 GO:0004857; F:enzyme inhibitor activity; IEA:Compara.
 GO:0009890; P:negative regulation of biosynthetic process; IEA:InterPro.
 GO:0043105; P:negative regulation of GTP cyclohydrolase I activity; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara. 

Interpro

 IPR009112; GTP_CycHdrlase_I_reg. 

Pfam

 PF06399; GFRP 

SMART

  

PROSITE

  

PRINTS