| Tag | Content |
|---|
| CPLM ID | CPLM-018172 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Heterogeneous nuclear ribonucleoprotein U-like protein 1 |
Protein Synonyms/Alias | |
Gene Name | Hnrnpul1 |
Gene Synonyms/Alias | Hnrpul1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 441 | GKTTWAIKHAASNPS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand- stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro (By similarity). |
Sequence Annotation | DOMAIN 3 37 SAP.
DOMAIN 192 389 B30.2/SPRY.
REPEAT 613 615 1-1.
REPEAT 620 622 1-2.
REPEAT 639 641 1-3.
REPEAT 645 647 1-4.
REPEAT 659 661 1-5.
REGION 1 103 Necessary for interaction with HRMT1L1
REGION 214 859 Necessary for interaction with TP53 (By
REGION 457 595 Necessary for interaction with BRD7 and
REGION 613 661 5 X 3 AA repeats of R-G-G.
REGION 613 661 Necessary for transcription repression
MOD_RES 195 195 Phosphoserine.
MOD_RES 513 513 Phosphoserine (By similarity).
MOD_RES 721 721 Phosphoserine (By similarity). |
Keyword | Activator; Alternative splicing; Complete proteome; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Ribonucleoprotein; RNA-binding; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 859 AA |
Protein Sequence | MDVRRLKVNE LREELQRRGL DTRGLKAELA ERLLAALEAE EPEDERELEA DDDPGLPGHN 60
NEEVETEGGS ELEGTAQPPP PGLQPHPEPG GYSGPDGHYV MDNITRQNQF YETPVIKQEN 120
ESSYDRRPLD MEPQQQVYHP ELKTEMKQEA PPSFLPPEAS QLKTDRPQFQ NRKRPFEENR 180
GRGYFEHRED RRGRSPQPPA EEDEDDFDDT LVAIDTYNCD LHFKVARDRS SGYPLTIEGF 240
AYLWSGARAS YGVRRGRVCF EMKINEEISV KHLPSTEPDP HVVRIGWSLD SCSTQLGEEP 300
FSYGYGGTGK KSTNSRFENY GDKFAENDVI GCFADFECGN DVELSFTKNG KWMGIAFRIQ 360
KEALGGQALY PHVLVKNCAV EFNFGQRAEP YCSVLPGFTF IQHLPLSERI RGTIGPKSKA 420
ECEILMMVGL PAAGKTTWAI KHAASNPSKK YNILGTNAIM DKMRVMGLRR QRNYAGRWDV 480
LIQQATQCLN RLIQIAARKK RNYILDQTNV YGSAQRRKMR PFEGFQRKAI VICPTDEDLK 540
DRTVKRTDEE GKDVPDHAVL EMKANFTLPD VGDFLDEVLF IELQREEADK LVRQYNEEGR 600
KAGPPPEKRF DSRGGGFRGR GGGGGFQRYD NRGPPGGNRG GFQNRGGGGG SGGGGGNYRG 660
GFNRSGGGGY NQNRWGNNNR DNNNSNNRGN YNRAPQQQPP PQQPPPPQPP PQQPPPPPSY 720
SPARNPPGAS SYNKNSNIPG SSANTSTPTV SSYTPPQPSY SQPPYNQGGY TQGYTAPPPP 780
PPPPPAYNYG SYGPYNPAPY TPPPPPTAQT YPQPSYNQYQ QYAQQWSQYY QNQSQWPPYY 840
GNYDYGGYSG STQGGTSTQ 859 |
Gene Ontology | GO:0005634; C:nucleus; ISS:UniProtKB. GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0009615; P:response to virus; IEA:InterPro. GO:0006396; P:RNA processing; IEA:InterPro. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |