CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030750
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calponin-3 
Protein Synonyms/Alias
 cDNA FLJ50126, highly similar to Calponin-3; cDNA, FLJ79297, highly similar to Calponin-3 
Gene Name
 CNN3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
115TRRFDEGKLKAGQSVacetylation[1]
117RFDEGKLKAGQSVIGubiquitination[2]
156DPKMQTDKPFDQTTIacetylation[1]
156DPKMQTDKPFDQTTIubiquitination[2]
171SLQMGTNKGASQAGMubiquitination[2, 3]
191RRDIYDQKLTLQPVDubiquitination[2, 3]
210SLQMGTNKVASQKGMubiquitination[2, 3]
215TNKVASQKGMSVYGLubiquitination[2, 4]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 288 AA 
Protein Sequence
MSIGPNFQLG LKDGIILCEL INKLQPGSVK KVNESSLNWP QLENIGNFIK AIQAYGMKPH 60
DIFEANDLFE NGNMTQVQTT LVALAGLAKT KGFHTTIDIG VKYAEKQTRR FDEGKLKAGQ 120
SVIGLQMGTN KCASQAGMTA YGTRRHLYDP KMQTDKPFDQ TTISLQMGTN KGASQAGMLA 180
PGTRRDIYDQ KLTLQPVDNS TISLQMGTNK VASQKGMSVY GLGRQVYDPK YCAAPTEPVI 240
HNGSQGTGTN GSEISDSDYQ AEYPDEYHGE YQDDYPRDYQ YSDQGIDY 288 
Gene Ontology
 GO:0031032; P:actomyosin structure organization; IEA:InterPro. 
Interpro
 IPR001997; Calponin.
 IPR000557; Calponin_repeat.
 IPR001715; CH-domain.
 IPR003096; SM22_calponin. 
Pfam
 PF00402; Calponin
 PF00307; CH 
SMART
 SM00033; CH 
PROSITE
 PS01052; CALPONIN_1
 PS51122; CALPONIN_2
 PS50021; CH 
PRINTS
 PR00889; CALPONIN.
 PR00888; SM22CALPONIN.