CPLM-018049

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-018049

UniProt Accession

ELP5_HUMAN; Q8TE02; A8K1M5; D3DTN9; Q659B6; Q7Z2T4; Q8TDR9; Q9BUB2; Q9Y2Q4

Genbank Protein ID

AF087868; AB013910; AK289940; AC003688; CH471108; CH471108; BC002762; AF070658; AF163262; AL713741

Genbank Nucleotide ID

AAM10496.1; BAB87800.1; BAF82629.1; EAW90230.1; EAW90231.1; AAH02762.2; AAD20964.1; AAQ13591.1; CAH56280.1

Protein Name

Elongator complex protein 5

Protein Synonyms/Alias

Dermal papilla-derived protein 6; S-phase 2 protein

Gene Name

ELP5

Gene Synonyms/Alias

C17orf81; DERP6; HSPC002; MSTP071

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
94	RDPLNWSKTEEAFPG	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.

Sequence Annotation

Keyword

Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

316 AA

Protein Sequence

MTPSEGARAG TGRELEMLDS LLALGGLVLL RDSVEWEGRS LLKALVKKSA LCGEQVHILG 60
CEVSEEEFRE GFDSDINNRL VYHDFFRDPL NWSKTEEAFP GGPLGALRAM CKRTDPVPVT 120
IALDSLSWLL LRLPCTTLCQ VLHAVSHQDS CPGDSSSVGK VSVLGLLHEE LHGPGPVGAL 180
SSLAQTEVTL GGTMGQASAH ILCRRPRQRP TDQTQWFSIL PDFSLDLQEG PSVESQPYSD 240
PHIPPVDPTT HLTFNLHLSK KEREARDSLI LPFQFSSEKQ QALLRPRPGQ ATSHIFYEPD 300
AYDDLDQEDP DDDLDI 316

Gene Ontology

GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0033588; C:Elongator holoenzyme complex; IDA:UniProtKB.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.

Interpro

IPR019519; Histone_acetylation_protein_2.

Pfam

PF10483; Hap2_elong

SMART

PROSITE

PRINTS