CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025230
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cGMP-dependent 3',5'-cyclic phosphodiesterase 
Protein Synonyms/Alias
  
Gene Name
 Pde2a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
128GPSDLLGKPLARLVAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 939 AA 
Protein Sequence
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPQP CADSLQDALL SLGAVIDIAG 60
LRQAARDALS AVLPKVETVY TYLLDGESRL VCEDPPHELP QEGKIREAVI SQKRLSCNGL 120
GPSDLLGKPL ARLVAPLAPD MQVLVIPLLD KETGSVAAVI LVHCGQLSDS EEQSLQVVEK 180
HALVALRRVQ ALQQRRPEAV QNTSVDASED QKDEKGYTDH DRKILQLCGE LFDLDATSLQ 240
LKVLQYLQQE TQATHCCLLL VSEDNLQLSC KVIGDKVLGE EVSFPLTMGR LGQVVEDKQC 300
IQLKDLTSDD VQQLQNMLGC ELQAMLCVPV ISRATDQVVA LACAFNKLGG DFPTSSFTDE 360
DEHVIQHCFH YTGTVLTSTL AFQKEQKLKC ECQALLQVAK NLFTHLDDVS VLLQEIITEA 420
RNLSNAEICS VFLLDQNELV AKVFDGGVVD DESYEIRIPA DQGIAGHVAT TGQILNIPDA 480
YAHPLFYRGV DDSTGFRTRN ILCFPIKNEN QEVIGVAELV NKINGPWFSK FDEDLATAFS 540
IYCGISIAHS LLYKKVNEAQ YRSHLANEMM MYHMKVSDDE YTKLLHDGIQ PVAAIDSNFA 600
NFTYTPRSLP EDDTSMAILS MLQDMNFINN YKIDCPTLAR FCLMVKKGYR DPPYHNWMHA 660
FSVSHFCYLL YKNLELSNYL EDIEIFALFI SCMCHDLDHR GTNNSFQVAS KSVLAALYSS 720
EGSVMERHHF AQAIAILNTH GCNIFDHFSR KDYQRMLDLM RDIILATDLA HHLRIFKDLQ 780
KMAEVGYDRN NRQHHRLLLC LLMTSCDLSD QTKGWKTTRK IAELIYKEFF SQGDLEKAMG 840
NRPMEMMDRE KAYIPELQIS FMEHIAMPIY KLLQDLFPKA AELYERVASN REHWTKVSHK 900
FTIRGLPSNN SLDFLDEEYE VPDLDGTRAP VNGCCSLEG 939 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030552; F:cAMP binding; IEA:Compara.
 GO:0030553; F:cGMP binding; IEA:Compara.
 GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IEA:Compara.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006198; P:cAMP catabolic process; IEA:Compara.
 GO:0019933; P:cAMP-mediated signaling; IEA:Compara.
 GO:0071321; P:cellular response to cGMP; IEA:Compara.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Compara.
 GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; IEA:Compara.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Compara.
 GO:0046069; P:cGMP catabolic process; IEA:Compara.
 GO:0019934; P:cGMP-mediated signaling; IEA:Compara.
 GO:0030224; P:monocyte differentiation; IEA:Compara.
 GO:0033159; P:negative regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0043116; P:negative regulation of vascular permeability; IEA:Compara.
 GO:0043117; P:positive regulation of vascular permeability; IEA:Compara. 
Interpro
 IPR003018; GAF.
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF01590; GAF
 PF00233; PDEase_I 
SMART
 SM00065; GAF
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.