CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005584
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium/calmodulin-dependent protein kinase I 
Protein Synonyms/Alias
  
Gene Name
 CMK1 
Gene Synonyms/Alias
 YFR014C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
271YWDSVSNKAKQFILKacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Important in cellular regulation. 
Sequence Annotation
 DOMAIN 37 299 Protein kinase.
 NP_BIND 43 51 ATP (By similarity).
 REGION 312 323 Calmodulin-binding (By similarity).
 ACT_SITE 161 161 Proton acceptor (By similarity).
 BINDING 66 66 ATP (By similarity).
 MOD_RES 417 417 Phosphoserine.
 MOD_RES 418 418 Phosphoserine.
 MOD_RES 420 420 Phosphoserine.
 MOD_RES 429 429 Phosphoserine.  
Keyword
 ATP-binding; Calmodulin-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 446 AA 
Protein Sequence
MDDKVSEKES SPKQTEEDSE GKMAHVQPAS YVNKKKYVFG KTLGAGTFGV VRQAKNTETG 60
EDVAVKILIK KALKGNKVQL EALYDELDIL QRLHHPNIVA FKDWFESKDK FYIITQLAKG 120
GELFDRILKK GKFTEEDAVR ILVEILSAVK YMHSQNIVHR DLKPENLLYI DKSDESPLVV 180
ADFGIAKRLK SDEELLYKPA GSLGYVAPEV LTQDGHGKPC DIWSIGVITY TLLCGYSAFR 240
AERVQDFLDE CTTGEYPVKF HRPYWDSVSN KAKQFILKAL NLDPSKRPTA AELLEDPWII 300
CTELKTHNLL PGLKEGLDAR QKFRNSVERV RLNMKIQKLR DLYLEQTESD SDFDEGSQAN 360
GSVPPLKATD TSQLSKKLSE EEQSKLKSEL TSKAFAQLVN TVLAEKEKFL NINRVCSSDS 420
DLPGSDIKSL DEAKEKPEGK DTKTEE 446 
Gene Ontology
 GO:0005737; C:cytoplasm; IPI:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004683; F:calmodulin-dependent protein kinase activity; IDA:SGD.
 GO:0007165; P:signal transduction; IMP:SGD. 
Interpro
 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS