CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-039874
UniProt Accession
F5H328_HUMAN
;
F5H328
Genbank Protein ID
AL031230
Genbank Nucleotide ID
Protein Name
Succinate-semialdehyde dehydrogenase, mitochondrial
Protein Synonyms/Alias
Gene Name
ALDH5A1
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Lysine Modification
Position
Peptide
Type
References
47
YNLMIQN
K
DDLARII
acetylation
[1]
Reference
[1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [
PMID: 23236377
]
Functional Description
Sequence Annotation
Keyword
Complete proteome; Oxidoreductase; Reference proteome.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
447 AA
Protein Sequence
MVADCGVREA RAAVRAAYEA FCRWREVSAK ERSSLLRKWY NLMIQNKDDL ARIITAESGK 60
PLKEAHGEIL YSAFFLEWFS EEARRVYGDI IHTPAKDRRA LVLKQPIGVA AVITPWNFPS 120
AMITRKVGAA LAAGCTVVVK PAEDTPFSAL ALAELASQAG IPSGVYNVIP CSRKNAKEVG 180
EAICTDPLVS KISFTGSTTT GKILLHHAAN SVKRVSMELG GLAPFIVFDS ANVDQAVAGA 240
MASKFRNTGQ TCVCSNQFLV QRGIHDAFVK AFAEAMKKNL RVGNGFEEGT TQGPLINEKA 300
VEKVEKQVND AVSKGATVVT GGKRHQLGKN FFEPTLLCNV TQDMLCTHEE TFGPLAPVIK 360
FDTEEEAIAI ANAADVGLAG YFYSQDPAQI WRVAEQLEVG MVGVNEGLIS SVECPFGGVK 420
QSGLGREGSK YGIDEYLELK YVCYGGL 447
Gene Ontology
GO:0005739
; C:mitochondrion; IDA:HPA.
GO:0009013
; F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
GO:0009450
; P:gamma-aminobutyric acid catabolic process; IEA:InterPro.
Interpro
IPR016161
; Ald_DH/histidinol_DH.
IPR016163
; Ald_DH_C.
IPR016160
; Ald_DH_CS.
IPR016162
; Ald_DH_N.
IPR015590
; Aldehyde_DH_dom.
IPR010102
; Succ_semiAld_DH.
Pfam
PF00171
; Aldedh
SMART
PROSITE
PS00070
; ALDEHYDE_DEHYDR_CYS
PS00687
; ALDEHYDE_DEHYDR_GLU
PRINTS