| Tag | Content |
|---|
| CPLM ID | CPLM-012739 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial |
Protein Synonyms/Alias | PEPCK-M; Phosphoenolpyruvate carboxylase |
Gene Name | PCK2 |
Gene Synonyms/Alias | PEPCK2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 410 | SWLGKPWKPGMCGGE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity). |
Sequence Annotation | NP_BIND 305 310 GTP (By similarity).
NP_BIND 548 551 GTP (By similarity).
REGION 421 423 Substrate binding (By similarity).
ACT_SITE 306 306 By similarity.
METAL 262 262 Manganese (By similarity).
METAL 282 282 Manganese (By similarity).
METAL 329 329 Manganese (By similarity).
BINDING 104 104 Substrate (By similarity).
BINDING 255 255 Substrate; via amide nitrogen (By
BINDING 262 262 Substrate (By similarity).
BINDING 304 304 Substrate (By similarity).
BINDING 423 423 GTP (By similarity).
BINDING 454 454 GTP (By similarity). |
Keyword | Alternative splicing; Complete proteome; Decarboxylase; Gluconeogenesis; GTP-binding; Lyase; Manganese; Metal-binding; Mitochondrion; Nucleotide-binding; Polymorphism; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 640 AA |
Protein Sequence | MAALYRPGLR LNWHGLSPLG WPSCRSIQTL RVLSGDLGQL PTGIRDFVEH SARLCQPEGI 60
HICDGTEAEN TATLTLLEQQ GLIRKLPKYN NCWLARTDPK DVARVESKTV IVTPSQRDTV 120
QLPPGGARGQ LGNWMSPADF QRAVDERFPG CMQGRTMYVL PFSMGPVGSP LSRIGVQLTD 180
SAYVVASMRI MTRLGTPVLQ ALGDGDFVKC LHSVGQPLTG QGEPVSQWPC NPEKTLIGHV 240
PDQREIISFG SGYGGNSLLG KKCFALRIAS RLARDEGWLA EHMLILGITS PAGKKRYVAA 300
AFPSACGKTN LAMMRPALPG WKVECVGDDI AWMRFDSEGR LRAINPENGF FGVAPGTSAT 360
TNPNAMATIQ SNTIFTNVAE TSDGGVYWEG IDQPLPPGVT VTSWLGKPWK PGMCGGEGVA 420
QPPGLSTLMV EKLSPQPPTI F 441 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; TAS:Reactome. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:EC. GO:0004611; F:phosphoenolpyruvate carboxykinase activity; TAS:ProtInc. GO:0006094; P:gluconeogenesis; TAS:Reactome. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |