UniProt Accession

 SC61G_YEAST; P35179; D6VS73 

Genbank Protein ID

 Z46796; X74499; X82086; Z74382; AY557659; BK006938 

Genbank Nucleotide ID

 CAA86808.1; CAA52608.1; CAA57615.1; CAA98906.1; AAS55985.1; DAA11933.1 

Protein Name

 Protein transport protein SSS1 

Protein Synonyms/Alias

 Sec61 complex subunit SSS1; Sec61 complex subunit gamma; Ssh1 complex subunit SSS1; Ssh1 complex subunit gamma 

Gene Name

 SSS1 

Gene Synonyms/Alias

 YDR086C; D4475 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
20	QSNNQVEKLVEAPVE	ubiquitination	[1]
38	EGTQFLAKCKKPDLK	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Part of the Sec61 complex, which is the major component of channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post- translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP- independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. Also part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein ER import. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Endoplasmic reticulum; Membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 80 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005784; C:Sec61 translocon complex; IDA:SGD.
 GO:0071261; C:Ssh1 translocon complex; IDA:SGD.
 GO:0015450; F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IMP:SGD.
 GO:0031204; P:posttranslational protein targeting to membrane, translocation; IDA:SGD.
 GO:0006616; P:SRP-dependent cotranslational protein targeting to membrane, translocation; IMP:SGD. 

Interpro

 IPR023391; Prot_translocase_SecE_dom.
 IPR027184; Sss1.
 IPR008158; Translocase_Sec61-g.
 IPR001901; Translocase_SecE/Sec61-g. 

Pfam

 PF00584; SecE 

SMART

  

PROSITE

 PS01067; SECE_SEC61G 

PRINTS