CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023803
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HBS1-like protein 
Protein Synonyms/Alias
 ERFS 
Gene Name
 HBS1L 
Gene Synonyms/Alias
 HBS1; KIAA1038 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47FIYSRRDKPSVEPVEubiquitination[1]
62EYDYEDLKESSNSVSubiquitination[1]
114KNKFDVQKALSGVLEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
 NP_BIND 267 274 GTP (By similarity).
 NP_BIND 344 348 GTP (By similarity).
 NP_BIND 406 409 GTP (By similarity).
 MOD_RES 117 117 Phosphoserine.
 MOD_RES 127 127 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Elongation factor; GTP-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 684 AA 
Protein Sequence
MARHRNVRGY NYDEDFEDDD LYGQSVEDDY CISPSTAAQF IYSRRDKPSV EPVEEYDYED 60
LKESSNSVSN HQLSGFDQAR LYSCLDHMRE VLGDAVPDEI LIEAVLKNKF DVQKALSGVL 120
EQDRVQSLKD KNEATVSTGK IAKGVLFSSS EVSADNVQSS YPQSANHLDY SSKPFDFASS 180
VGKYGLSHNS SVPTHCLLHR KKKLDTRKSE KKLESCKLTK ELSLANLIHD MSRDSCESQP 240
SVRLSSTDSL ESLLSKNLDA DLLRPHASEC ISKDDSAFKE IPDLKTIIIK GTTPNNSLYI 300
QNNSLSDFQN IPVQDSLGSS NNPLYLTSSL ENMTVDNLNA SKETEVGNVS LVEQSAKNHT 360
FKNDNLQFSQ CESPSLTELF QEHKENNISQ CFTLSDLCNQ SSASFTDLSL GSFPLSQLAN 420
RCQSSPGISE LTGSLSSLAF HKASPTRDLE NLSLSELIAE TIDVDNSQIK KESFEVSLSE 480
VRSPGIDSNI DLSVLIKNPD FVPKPVVDPS IAPSSRTKVL SSKLGKNSNF AKDNKKNNKG 540
SLTRKPPFSL SWTKALAARP SAFASTLCLR YPLKSCKRRT LDLYKTFLYS RQVQDVKDKE 600
ISPLVAITPF DFKSASPDDI VKANQKKAFT RE 632 
Gene Ontology
 GO:0005525; F:GTP binding; TAS:ProtInc.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0007165; P:signal transduction; TAS:ProtInc.
 GO:0006412; P:translation; TAS:ProtInc. 
Interpro
 IPR015033; DUF1916.
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF08938; DUF1916
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 
SMART
  
PROSITE
 PS00301; EFACTOR_GTP 
PRINTS
 PR00315; ELONGATNFCT.