CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015027
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenosylhomocysteinase 
Protein Synonyms/Alias
 S-adenosyl-L-homocysteine hydrolase; AdoHcyase 
Gene Name
 ahcY 
Gene Synonyms/Alias
 RPA4015 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
418QNQGKYEKKVYVLPKacetylation[1]
Reference
 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131] 
Functional Description
 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity). 
Sequence Annotation
 NP_BIND 196 198 NAD (By similarity).
 NP_BIND 259 264 NAD (By similarity).
 NP_BIND 338 340 NAD (By similarity).
 BINDING 58 58 Substrate (By similarity).
 BINDING 133 133 Substrate (By similarity).
 BINDING 195 195 Substrate (By similarity).
 BINDING 225 225 Substrate (By similarity).
 BINDING 229 229 Substrate (By similarity).
 BINDING 230 230 NAD (By similarity).
 BINDING 282 282 NAD (By similarity).
 BINDING 317 317 NAD (By similarity).
 BINDING 383 383 NAD (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Hydrolase; NAD; One-carbon metabolism. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 469 AA 
Protein Sequence
MTAKFTDYIV KDIGLAEFGR KEISLAETEM PGLMATREEY GPKQPLKGAK IAGSLHMTIQ 60
TAVLIETLVA LGAEVRWVSC NIYSTQDHAA AAIAAAGIPV FAVKGETLKD YWDYTAKLFD 120
WSDGGTPNMI LDDGGDATMF VHQGLRAENG DTMFLDQHNS EEEEIFFALI KRILKEKPKG 180
YFATLAKNIK GVSEETTTGV HRLYDMEKAG KLLFPAINVN DSVTKSKFDN LYGCRESLVD 240
GIRRGTDVML SGKVAMVAGF GDVGKGSAAS LRQAGCRVMV SEVDPICALQ AAMEGYQVVT 300
MEDAAPIADI FVTATGNKDI ITIEHMRAMK DRAIVCNIGH FDNEIQVATL KNMKWDNIKP 360
QVDEITFPDG KRMILLSEGR LVNLGNAMGH PSFVMSASFT NQTLAQIELF QNQGKYEKKV 420
YVLPKTLDEK VARLHLAKIG VKLTELRKDQ ADYIGVKVEG PFKADHYRY 469 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004013; F:adenosylhomocysteinase activity; IEA:HAMAP.
 GO:0006730; P:one-carbon metabolic process; IEA:HAMAP. 
Interpro
 IPR000043; Adenosylhomocysteinase.
 IPR015878; Ado_hCys_hydrolase_NAD-bd.
 IPR016040; NAD(P)-bd_dom.
 IPR020082; S-Ado-L-homoCys_hydrolase_CS. 
Pfam
 PF05221; AdoHcyase
 PF00670; AdoHcyase_NAD 
SMART
 SM00996; AdoHcyase
 SM00997; AdoHcyase_NAD 
PROSITE
 PS00738; ADOHCYASE_1
 PS00739; ADOHCYASE_2 
PRINTS