CPLM-029753

Genbank Nucleotide ID

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
8	MAQQAADKYLYVDKN	acetylation	[1, 2, 3]
8	MAQQAADKYLYVDKN	methylation	[4]
8	MAQQAADKYLYVDKN	ubiquitination	[3, 5, 6]
14	DKYLYVDKNFINNPL	acetylation	[2]
14	DKYLYVDKNFINNPL	ubiquitination	[3, 5, 6, 7]
29	AQADWAAKKLVWVPS	acetylation	[1]
29	AQADWAAKKLVWVPS	ubiquitination	[6, 7, 8]
30	QADWAAKKLVWVPSD	ubiquitination	[6]
38	LVWVPSDKSGFEPAS	ubiquitination	[5]
64	ELVENGKKVKVNKDD	ubiquitination	[6]
66	VENGKKVKVNKDDIQ	ubiquitination	[3, 6]
69	GKKVKVNKDDIQKMN	ubiquitination	[7]
74	VNKDDIQKMNPPKFS	acetylation	[1, 3]
79	IQKMNPPKFSKVEDM	acetylation	[2]
82	MNPPKFSKVEDMAEL	ubiquitination	[6]

[1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
[2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]
[3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
[4] Large-scale global identification of protein lysine methylation in vivo.
Cao XJ, Arnaudo AM, Garcia BA.
Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
[5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[8] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Complete proteome; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005913; C:cell-cell adherens junction; IEA:Compara.
GO:0030863; C:cortical cytoskeleton; IEA:Compara.
GO:0001772; C:immunological synapse; IEA:Compara.
GO:0016460; C:myosin II complex; IEA:Compara.
GO:0031594; C:neuromuscular junction; IEA:Compara.
GO:0005819; C:spindle; IEA:Compara.
GO:0001931; C:uropod; IEA:Compara.
GO:0005524; F:ATP binding; IEA:InterPro.
GO:0003774; F:motor activity; IEA:InterPro.
GO:0000904; P:cell morphogenesis involved in differentiation; IEA:Compara.
GO:0016337; P:cell-cell adhesion; IEA:Compara.
GO:0006928; P:cellular component movement; IEA:Compara.
GO:0051295; P:establishment of meiotic spindle localization; IEA:Compara.
GO:0001768; P:establishment of T cell polarity; IEA:Compara.
GO:0001701; P:in utero embryonic development; IEA:Compara.
GO:0000212; P:meiotic spindle organization; IEA:Compara.
GO:0007520; P:myoblast fusion; IEA:Compara.
GO:0032796; P:uropod organization; IEA:Compara.

IPR004009; Myosin_N.
IPR008989; Myosin_S1_N.