CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009980
UniProt Accession
Genbank Protein ID
 U59240 
Genbank Nucleotide ID
Protein Name
 Tropomodulin-2 
Protein Synonyms/Alias
 Neuronal tropomodulin; N-Tmod 
Gene Name
 Tmod2 
Gene Synonyms/Alias
 Ntmod 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
81EKEALEQKDREDFVPubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). 
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MALPFQKGLE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESATLPAGF RQKDQTQKAA 60
TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP KEKPVETRKE EKVTLDPELE 120
EALASASDTE LYDLAAVLGV HNLLNNPKFD EETTNGQGRK GPVRNVVKGE KAKPVFEEPP 180
NPTNVEASLQ QMKANDPSLQ EVNLNNIKNI PIPTLKEFAK ALETNTHVRK FSLAATRSND 240
PVALAFAEML KVNKTLKSLN VESNFITGAG ILALVEALRE NDTLTEIKID NQRQQLGTAV 300
EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEGDR R 351 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; IDA:RGD.
 GO:0003779; F:actin binding; IDA:RGD.
 GO:0005523; F:tropomyosin binding; IDA:RGD.
 GO:0007015; P:actin filament organization; TAS:RGD.
 GO:0007611; P:learning or memory; IEA:Compara.
 GO:0007270; P:neuron-neuron synaptic transmission; IEA:Compara.
 GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IEA:Compara. 
Interpro
 IPR004934; Tropomodulin. 
Pfam
 PF03250; Tropomodulin 
SMART
  
PROSITE
  
PRINTS