UniProt Accession

 VATC_YEAST; P31412; D6VXK7 

Genbank Protein ID

 M77143; X75560; Z28080; BK006944 

Genbank Nucleotide ID

 AAA34440.1; CAA53237.1; CAA81917.1; DAA09077.1 

Protein Name

 V-type proton ATPase subunit C 

Protein Synonyms/Alias

 V-ATPase subunit C; V-ATPase 42 kDa subunit; Vacuolar proton pump subunit C 

Gene Name

 VMA5 

Gene Synonyms/Alias

 VAT3; VATC; YKL080W; YKL410 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
49	RAFVSDFKIPEFKIG	acetylation	[1]
203	VAVPKSLKSDFEKSY	acetylation	[1]
208	SLKSDFEKSYETLSK	ubiquitination	[2]
241	FNVHLFKKNVQEFTT	acetylation	[1]
271	EELIDQLKKEHDSAA	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C acts as a flexible stator that holds together the catalytic and the membrane sectors of the enzyme. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section. Binds ATP and is likely to have a specific function in the catalytic activity of the catalytic sector. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; ATP-binding; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Nucleotide-binding; Reference proteome; Transport; Vacuole. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0000329; C:fungal-type vacuole membrane; TAS:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; TAS:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; TAS:SGD.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0007035; P:vacuolar acidification; TAS:SGD. 

Interpro

 IPR004907; ATPase_V1-cplx_csu. 

Pfam

 PF03223; V-ATPase_C 

SMART

  

PROSITE

  

PRINTS