UniProt Accession

 RCD1_RAT; Q5PQL2 

Genbank Protein ID

 BC087134 

Genbank Nucleotide ID

 AAH87134.1 

Protein Name

 Cell differentiation protein RCD1 homolog 

Protein Synonyms/Alias

 Rcd-1; CCR4-NOT transcription complex subunit 9 

Gene Name

 Rqcd1 

Gene Synonyms/Alias

 Cnot9; Rcd1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
230	EPSARLLKHVVRCYL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation (By similarity). 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Activator; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repressor; RNA-mediated gene silencing; Transcription; Transcription regulation; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
 GO:0000932; C:cytoplasmic mRNA processing body; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
 GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
 GO:2000327; P:positive regulation of ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR007216; Rcd1. 

Pfam

 PF04078; Rcd1 

SMART

  

PROSITE

  

PRINTS