| Tag | Content |
|---|
| CPLM ID | CPLM-017211 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tudor domain-containing protein 7 |
Protein Synonyms/Alias | PCTAIRE2-binding protein; Tudor repeat associator with PCTAIRE-2; Trap |
Gene Name | Tdrd7 |
Gene Synonyms/Alias | Pctaire2bp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 400 | KLPLPTDKILKDEGQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis. |
Sequence Annotation | DOMAIN 3 76 HTH OST-type 1.
DOMAIN 222 291 HTH OST-type 2.
DOMAIN 325 394 HTH OST-type 3.
DOMAIN 501 558 Tudor 1.
DOMAIN 691 748 Tudor 2.
REGION 849 1086 Interacts with CDK17 (By similarity).
REGION 881 1086 Interacts with CABLES1. |
Keyword | 3D-structure; Cataract; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Reference proteome; Repeat; RNA-binding; Spermatogenesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1086 AA |
Protein Sequence | MLEADLVSKM LRAVLQSHKN GIVLPRLQGE YRSLTGDWIP FKQLGYPTLE AYLRSVPAVV 60
RIEASRSGEI VCYAVACTET ARIAQLVARQ RTSKRKIGRQ INCQMRVKKA MPFFLEGKPK 120
ATLRQPGFAS DYSISRKPNS ALLRDRGSAL GVKADVDMPP YPDTPVQRHA SMSANSRFSP 180
KSSLPASFQT HISRACPTEV NDNLNQTVEK PNITPPASYT NKMDEVQNRI KEILDKHNNG 240
IWISKLPHFY KEFYKEDLNQ GVLQQFEHWP HICTVEKPCG GGQDSLLYPA RREQPLKSDQ 300
DPEKELPPPP PAPKQEVPSQ GSPAVMPDVK EKVAELLGKY SSGLWASALP KAFEDMYKVK 360
FPEDALKNLA SLSDVCTINY ISGNTQKAIL YAKLPLPTDK ILKDEGQAQG DFDIKSMIEQ 420
EYLQIEKNMA ESADEFLEDI TVPPLVIPTE ASPSVLVVEL SNTNDVVIRY VGKDYSAAQE 480
LMEDEMKEFY SKNPRVTPIQ TVHVGQLLAV NAEEDAWLRA QIISTDENKI KVCYVDYGFC 540
ENIEKSKAYR LNPRFCSLSF QATKCKLAGL EVLNDDPDLV KAVESLTCGK IFAVEILDKS 600
DVPLVVLYDT SGEDDININA TCLKAICDRS LQVHLQVDAM YTNVKVTNIC SDGTLYCQVP 660
CKGLNKLNDL LHKTEDYFHC KHMTSEYFIS LPFCGKICLF HCKGKWLRVE ITNVHSSRAL 720
DVQFLDSGNS TSVKVSELRE IPPRFLQEML AIPPQAIKCC LADLPQSIGM WTPDAVLWLR 780
DSVLNCSDCS IKVTKMDETK GVAYVYLFTP NNFPDPHRSI NRQITNADLW KHQKDVFLSA 840
VSTAASSPGN RNGGTPAPGS PAESLRKSHP EVIKKSVLDH TSSFSLEELP PPVHLSRSGE 900
HMDVYVPVAC HPGHFVIQPW QEIHKLEVLM EEMILYYSVS EERHIAVERD QVYAAKVENK 960
WYRVLLKGIL TNGLVSVYEL DYGKHELVNI RKVQPLVDVF RKLPFQAVTA QLAGVKCSQW 1020
SEEASMVFRN HVEKKALVAL VQTVVEHTNP WDRKVVLYLV DTSLPDTDTW IHDFMSQYLL 1080
ELSKVN 1086 |
Gene Ontology | GO:0033391; C:chromatoid body; IDA:UniProtKB. GO:0005759; C:mitochondrial matrix; IEA:Compara. GO:0043186; C:P granule; IDA:MGI. GO:0003729; F:mRNA binding; ISS:UniProtKB. GO:0007281; P:germ cell development; IDA:MGI. GO:0070306; P:lens fiber cell differentiation; IMP:UniProtKB. GO:0002089; P:lens morphogenesis in camera-type eye; IMP:UniProtKB. GO:0010608; P:posttranscriptional regulation of gene expression; ISS:UniProtKB. GO:0007283; P:spermatogenesis; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |