CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020052
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Allograft inflammatory factor 1-like 
Protein Synonyms/Alias
 Ionized calcium-binding adapter molecule 2 
Gene Name
 AIF1L 
Gene Synonyms/Alias
 C9orf58; IBA2; UNQ672/PRO1306 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13SNRFQGGKAFGLLKAubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
 Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function. 
Sequence Annotation
 DOMAIN 47 82 EF-hand 1.
 DOMAIN 83 117 EF-hand 2; degenerate.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Actin-binding; Alternative splicing; Calcium; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 150 AA 
Protein Sequence
MSGELSNRFQ GGKAFGLLKA RQERRLAEIN REFLCDQKYS DEENLPEKLT AFKEKYMEFD 60
LNNEGEIDLM SLKRMMEKLG VPKTHLEMKK MISEVTGGVS DTISYRDFVN MMLGKRSAVL 120
KLVMMFEGKA NESSPKPVGP PPERDIASLP 150 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:LIFEdb.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005925; C:focal adhesion; IDA:LIFEdb.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
 GO:0051015; F:actin filament binding; IDA:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom. 
Pfam
  
SMART
  
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS