UniProt Accession

 Q6N018_HUMAN; Q6N018 

Genbank Protein ID

 AC092658; BX640744 

Genbank Nucleotide ID

 CAE45855.1 

Protein Name

 Kelch-like protein 8 

Protein Synonyms/Alias

 Putative uncharacterized protein DKFZp686H07112 

Gene Name

 DKFZp686H07112 

Gene Synonyms/Alias

 KLHL8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
152	DLNIENEKQVYNAAI	ubiquitination	[1, 2, 3]
171	ANPQHHSKWLDETLA	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kelch repeat; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 544 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR011705; BACK.
 IPR015916; Gal_Oxidase_b-propeller.
 IPR017096; Kelch-like_gigaxonin.
 IPR006652; Kelch_1. 

Pfam

 PF07707; BACK
 PF01344; Kelch_1 

SMART

 SM00875; BACK
 SM00612; Kelch 

PROSITE

  

PRINTS