| Tag | Content |
|---|
| CPLM ID | CPLM-020770 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Endoplasmic reticulum resident protein 44 |
Protein Synonyms/Alias | ER protein 44; ERp44; Thioredoxin domain-containing protein 4 |
Gene Name | Erp44 |
Gene Synonyms/Alias | Kiaa0573; Txndc4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 200 | SAFGDLSKPERYNGD | acetylation | [1] | | 303 | FLHADCDKFRHPLLH | acetylation | [1] | | 345 | VLIPGKLKQFVFDLH | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum (By similarity). |
Sequence Annotation | DOMAIN 30 138 Thioredoxin.
REGION 236 285 Interaction with ITPR1.
MOTIF 403 406 Prevents secretion from ER (Potential).
DISULFID 189 241 By similarity.
DISULFID 301 318 By similarity. |
Keyword | Chaperone; Complete proteome; Disulfide bond; Endoplasmic reticulum; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 406 AA |
Protein Sequence | MNPAVFLSLA DLRCSLLLLV TSIFTPITAE IASLDSENID EILNNADVAL VNFYADWCRF 60
SQMLHPIFEE ASDVIKEEYP DKNQVVFARV DCDQHSDIAQ RYRISKYPTL KLFRNGMMMK 120
REYRGQRSVK ALADYIRQQK SNPVHEIQSL DEVTNLDRSK RNIIGYFEQK DSENYRVFER 180
VASILHDDCA FLSAFGDLSK PERYNGDNVI YKPPGRSAPD MVYLGSMTNF DVTYNWIQDK 240
CVPLVREITF ENGEELTEEG LPFLILFHMK DDTESLEIFQ NEVARQLISE KGTINFLHAD 300
CDKFRHPLLH IQKTPADCPV IAIDSFRHMY VFGDFKDVLI PGKLKQFVFD LHSGKLHREF 360
HHGPDPTDTA PGEQDQDVAS SPPESSFQKL APSEYRYTLL RDRDEL 406 |
Gene Ontology | GO:0009986; C:cell surface; IDA:MGI. GO:0005788; C:endoplasmic reticulum lumen; ISS:UniProtKB. GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB. GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:Compara. GO:0003756; F:protein disulfide isomerase activity; ISS:UniProtKB. GO:0045454; P:cell redox homeostasis; IEA:InterPro. GO:0009100; P:glycoprotein metabolic process; ISS:UniProtKB. GO:0006986; P:response to unfolded protein; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
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