UniProt Accession

 HPPD_HUMAN; P32754; A8K461; B3KQ63; Q13234 

Genbank Protein ID

 D31628; X72389; U29895; AK057510; AK290826; AC069503; AC079360; CH471054; BC024287 

Genbank Nucleotide ID

 BAA06498.1; CAA51082.1; AAC73008.1; BAG51925.1; BAF83515.1; EAW98292.1; AAH24287.1 

Protein Name

 4-hydroxyphenylpyruvate dioxygenase 

Protein Synonyms/Alias

 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase 

Gene Name

 HPD 

Gene Synonyms/Alias

 PPD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
39	AASFYCSKMGFEPLA	ubiquitination	[1]
63	EVVSHVIKQGKIVFV	ubiquitination	[1]
80	SALNPWNKEMGDHLV	ubiquitination	[1]
94	VKHGDGVKDIAFEVE	ubiquitination	[1]
109	DCDYIVQKARERGAK	ubiquitination	[1]
127	EPWVEQDKFGKVKFA	ubiquitination	[1]
175	PLLPKLPKCSLEMID	ubiquitination	[1]
202	SASEWYLKNLQFHRF	ubiquitination	[1]
237	ANYEESIKMPINEPA	ubiquitination	[1]
247	INEPAPGKKKSQIQE	ubiquitination	[1]
249	EPAPGKKKSQIQEYV	ubiquitination	[1]
270	GVQHIALKTEDIITA	ubiquitination	[1]
297	SVPSTYYKQLREKLK	ubiquitination	[1, 2, 3]
311	KTAKIKVKENIDALE	ubiquitination	[1]
369	GNFNSLFKAFEEEQN	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Key enzyme in the degradation of tyrosine. 

Sequence Annotation

 METAL 183 183 Iron (Probable).
 METAL 266 266 Iron (Probable).
 METAL 349 349 Iron (Probable).
 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 250 250 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Dioxygenase; Disease mutation; Iron; Mental retardation; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Phosphoprotein; Polymorphism; Reference proteome; Tyrosine catabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0006559; P:L-phenylalanine catabolic process; TAS:Reactome.
 GO:0006572; P:tyrosine catabolic process; ISS:UniProtKB. 

Interpro

 IPR005956; 4OHPhenylPyrv_dOase.
 IPR004360; Glyas_Fos-R_dOase_dom. 

Pfam

 PF00903; Glyoxalase 

SMART

  

PROSITE

  

PRINTS