UniProt Accession

 STXB1_RAT; P61765; Q28208; Q62759; Q64320; Q96TG8 

Genbank Protein ID

 L26087; L26264; U06069; U21116; BC088850 

Genbank Nucleotide ID

 AAB41113.1; AAA19246.1; AAA17987.1; AAA96350.1; AAH88850.1 

Protein Name

 Syntaxin-binding protein 1 

Protein Synonyms/Alias

 N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67; rbSec1 

Gene Name

 Stxbp1 

Gene Synonyms/Alias

 Unc18a 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
7	*MAPIGLKAVVGEKI	acetylation	[1]
13	LKAVVGEKIMHDVIK	acetylation	[1]
13	LKAVVGEKIMHDVIK	ubiquitination	[2]
20	KIMHDVIKKVKKKGE	acetylation	[1]
92	HSLISDFKDPPTAKY	acetylation	[1]
92	HSLISDFKDPPTAKY	ubiquitination	[2]
98	FKDPPTAKYRAAHVF	acetylation	[1]
294	LWIALRHKHIAEVSQ	acetylation	[1]
294	LWIALRHKHIAEVSQ	ubiquitination	[2]
308	QEVTRSLKDFSSSKR	acetylation	[1]
308	QEVTRSLKDFSSSKR	ubiquitination	[2]
332	RDLSQMLKKMPQYQK	acetylation	[1]
339	KKMPQYQKELSKYST	acetylation	[1]
382	GTDAEGEKIKDPMRA	acetylation	[1]
384	DAEGEKIKDPMRAIV	acetylation	[1]
493	MEDTIEDKLDTKHYP	acetylation	[1]
497	IEDKLDTKHYPYIST	acetylation	[1]
497	IEDKLDTKHYPYIST	ubiquitination	[2]
583	QKLLDTLKKLNKTDE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. 

Sequence Annotation

 MOD_RES 107 107 Phosphothreonine (By similarity).
 MOD_RES 142 142 Phosphoserine (By similarity).
 MOD_RES 145 145 Phosphotyrosine (By similarity).
 MOD_RES 146 146 Phosphoserine (By similarity).
 MOD_RES 345 345 Phosphoserine (By similarity).
 MOD_RES 346 346 Phosphothreonine (By similarity).
 MOD_RES 473 473 Phosphotyrosine (By similarity).
 MOD_RES 507 507 Phosphoserine (By similarity).
 MOD_RES 509 509 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 594 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0031091; C:platelet alpha granule; IEA:Compara.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0019904; F:protein domain specific binding; IDA:RGD.
 GO:0047485; F:protein N-terminus binding; IDA:RGD.
 GO:0017075; F:syntaxin-1 binding; IDA:MGI.
 GO:0007412; P:axon target recognition; IEA:Compara.
 GO:0060292; P:long term synaptic depression; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0032229; P:negative regulation of synaptic transmission, GABAergic; IEA:Compara.
 GO:0007274; P:neuromuscular synaptic transmission; IEA:Compara.
 GO:0007269; P:neurotransmitter secretion; IEA:Compara.
 GO:0070527; P:platelet aggregation; IEA:Compara.
 GO:0002576; P:platelet degranulation; IEA:Compara.
 GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Compara.
 GO:0045921; P:positive regulation of exocytosis; IMP:RGD.
 GO:0050821; P:protein stabilization; IDA:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0010807; P:regulation of synaptic vesicle priming; IMP:RGD.
 GO:0016188; P:synaptic vesicle maturation; IEA:Compara.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:Compara. 

Interpro

 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 

Pfam

 PF00995; Sec1 

SMART

  

PROSITE

  

PRINTS