CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020861
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisomal sarcosine oxidase 
Protein Synonyms/Alias
 PSO; L-pipecolate oxidase; L-pipecolic acid oxidase 
Gene Name
 Pipox 
Gene Synonyms/Alias
 Pso 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
57GQSRIIRKAYPEDFYubiquitination[1]
98ELLLLGTKENPGLKTacetylation[2, 3]
98ELLLLGTKENPGLKTubiquitination[1]
104TKENPGLKTIQATLSubiquitination[1]
126YLSSVDLKQRFPNIRacetylation[2, 3]
126YLSSVDLKQRFPNIRubiquitination[1]
144GEVGLLDKTGGVLYAubiquitination[1]
153GGVLYADKALRALQHubiquitination[1]
187PGLPVTVKTTLKSYQubiquitination[1]
287PEERDCPKTFSDIQDacetylation[2, 3]
287PEERDCPKTFSDIQDubiquitination[1]
352GFSGHGFKLAPVVGKubiquitination[1]
359KLAPVVGKILYELSMubiquitination[1]
387SRFSTLSKAHL****acetylation[4]
387SRFSTLSKAHL****succinylation[4]
387SRFSTLSKAHL****ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Metabolizes sarcosine, L-pipecolic acid and L-proline (By similarity). 
Sequence Annotation
 NP_BIND 9 39 FAD (Potential).
 MOTIF 388 390 Microbody targeting signal (Potential).
 MOD_RES 319 319 S-8alpha-FAD cysteine (Probable).  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Peroxisome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 390 AA 
Protein Sequence
MAAQTDFWDA IVIGAGIQGC FTAYHLAKHS KSVLLLEQFF LPHSRGSSHG QSRIIRKAYP 60
EDFYTMMMKE CYQTWAQLER EAGTQLHRQT ELLLLGTKEN PGLKTIQATL SRQGIDHEYL 120
SSVDLKQRFP NIRFTRGEVG LLDKTGGVLY ADKALRALQH IICQLGGTVC DGEKVVEIRP 180
GLPVTVKTTL KSYQANSLVI TAGPWTNRLL HPLGIELPLQ TLRINVCYWR EKVPGSYGVS 240
QAFPCILGLD LAPHHIYGLP ASEYPGLMKI CYHHGDNVDP EERDCPKTFS DIQDVQILCH 300
FVRDHLPGLR AEPDIMERCM YTNTPDEHFI LDCHPKYDNI VIGAGFSGHG FKLAPVVGKI 360
LYELSMKLPP SYDLAPFRMS RFSTLSKAHL 390 
Gene Ontology
 GO:0005777; C:peroxisome; IDA:HGNC.
 GO:0050031; F:L-pipecolate oxidase activity; ISS:UniProtKB.
 GO:0008115; F:sarcosine oxidase activity; ISS:UniProtKB.
 GO:0033514; P:L-lysine catabolic process to acetyl-CoA via L-pipecolate; ISS:UniProtKB.
 GO:0046653; P:tetrahydrofolate metabolic process; IEA:InterPro. 
Interpro
 IPR006076; FAD-dep_OxRdtase.
 IPR006281; SoxA_mon. 
Pfam
 PF01266; DAO 
SMART
  
PROSITE
  
PRINTS