CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009044
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 C-terminal-binding protein 2 
Protein Synonyms/Alias
 CtBP2 
Gene Name
 CTBP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
819RGGLVDEKALAQALKubiquitination[1]
826KALAQALKEGRIRGAubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). 
Sequence Annotation
 NP_BIND 186 191 NAD.
 NP_BIND 243 249 NAD.
 NP_BIND 270 272 NAD.
 NP_BIND 321 324 NAD.
 ACT_SITE 272 272 By similarity.
 ACT_SITE 301 301 By similarity.
 ACT_SITE 321 321 Proton donor (By similarity).
 BINDING 106 106 NAD (By similarity).
 BINDING 210 210 NAD.
 BINDING 296 296 NAD.  
Keyword
 3D-structure; Alternative splicing; Cell junction; Complete proteome; Differentiation; Direct protein sequencing; NAD; Nucleus; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Synapse; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 445 AA 
Protein Sequence
MPVPSRHINI GRSQSWDAAG WYEGPWENAE SLRPLGRRSS LTYGTAEGTW FEPNHRPQDA 60
ALPVAAEPYL YREAVYNSVA ARKGSTPDFT FYDSRQAVMS GRSPLLPREY YSDPSGAARV 120
PKEPPLYRDP GVSRPVPSYG VLGSRTSWDP MQGRSPALQD AGHLYRDPGG KMIPQGRQTQ 180
SRAASPGRYG REQPDTRYGA EVPAYPLSQV FSDISERPID PAPARQVAPT CLVVDPSSAA 240
APEGSTGVAP GALNRGYGPA RESIPSKMAY ETYEADLSTF QGPGGKRTVL PEFLAFLRAE 300
GLAEATLGAL LQQGFDSPAV LATLEDADIK SVAPNLGQAR VLSRLANSCR TEMQLRRQDR 360
GGPLPRARSS SFSHRSELLH GDLASLGAAA PLQTASPRAG DPARRPSSAP SQHLLETAAT 420
YSAPGVGTHA PHFPSNSGYS SPTPCALTAR LSPTYPLQAG VALTNPGPSN PLHPGPRTAY 480
STAYTVPMEL LKRERNVAAS PLPSPHGSPQ VLRKPGAPLG PSTLPPASQS LHTPHSPYQK 540
VARRTGAPII VSTMLAPEPS IRPQIMNGPL HPRPLVALLD GRDCTVEMPI LKDLATVAFC 600
DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV IVRIGSGYDN VDIKAAGELG 660
IAVCNIPSAA VEETADSTIC HILNLYRRNT WLYQALREGT RVQSVEQIRE VASGAARIRG 720
ETLGLIGFGR TGQAVAVRAK AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS 780
LHCNLNEHNH HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES 840
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP ESLRNCVNKE 900
FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP AAMEGIIPGG IPVTHNLPTV 960
AHPSQAPSPN QPTKHGDNRE HPNEQ 985 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0017053; C:transcriptional repressor complex; ISS:UniProtKB.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0019079; P:viral genome replication; TAS:ProtInc.
 GO:0050872; P:white fat cell differentiation; ISS:UniProtKB. 
Interpro
 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C 
SMART
  
PROSITE
 PS00065; D_2_HYDROXYACID_DH_1
 PS00670; D_2_HYDROXYACID_DH_2
 PS00671; D_2_HYDROXYACID_DH_3 
PRINTS