UniProt Accession

 ROA1_HUMAN; P09651; A8K4Z8; Q3MIB7; Q6PJZ7 

Genbank Protein ID

 X12671; X06747; X79536; AK291113; AC078778; CH471054; BC002355; BC009600; BC012158; BC033714; BC052296; BC070315; BC074502; BC103707; X04347 

Genbank Nucleotide ID

 CAA31191.1; CAA29922.1; CAA56072.1; BAF83802.1; EAW96761.1; AAH02355.1; AAH09600.1; AAH12158.1; AAH33714.1; AAH52296.1; AAH70315.1; AAH74502.1; AAI03708.1; CAA27874.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein A1 

Protein Synonyms/Alias

 hnRNP A1; Helix-destabilizing protein; Single-strand RNA-binding protein; hnRNP core protein A1 

Gene Name

 HNRNPA1 

Gene Synonyms/Alias

 HNRPA1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MSKSESPKEPEQLRK	ubiquitination	[1]
15	KEPEQLRKLFIGGLS	ubiquitination	[1]
52	VMRDPNTKRSRGFGF	ubiquitination	[2]
78	AMNARPHKVDGRVVE	ubiquitination	[1]
166	VDKIVIQKYHTVNGH	ubiquitination	[1]
183	EVRKALSKQEMASAS	ubiquitination	[1, 2]
277	SSNFGPMKGGNFGGR	ubiquitination	[2]
298	GGGQYFAKPRNQGGY	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. 

Sequence Annotation

 DOMAIN 14 97 RRM 1.
 DOMAIN 105 184 RRM 2.
 REGION 4 94 Globular A domain.
 REGION 95 185 Globular B domain.
 REGION 218 240 RNA-binding RGG-box.
 REGION 320 357 Nuclear targeting sequence (M9).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.
 MOD_RES 3 3 N6-acetyllysine.
 MOD_RES 4 4 Phosphoserine.
 MOD_RES 6 6 Phosphoserine.
 MOD_RES 192 192 Phosphoserine; by MKNK2.
 MOD_RES 194 194 Asymmetric dimethylarginine; alternate
 MOD_RES 194 194 Dimethylated arginine; alternate.
 MOD_RES 199 199 Phosphoserine.
 MOD_RES 206 206 Dimethylated arginine; alternate.
 MOD_RES 206 206 Omega-N-methylarginine; alternate.
 MOD_RES 225 225 Dimethylated arginine; alternate.
 MOD_RES 225 225 Omega-N-methylarginine; alternate.
 MOD_RES 350 350 N6-acetyllysine.
 MOD_RES 362 362 Phosphoserine; by MKNK2.
 MOD_RES 363 363 Phosphoserine; by MKNK2.
 MOD_RES 364 364 Phosphoserine; by MKNK2.
 MOD_RES 365 365 Phosphoserine.
 MOD_RES 368 368 Phosphoserine.
 CROSSLNK 113 113 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Isopeptide bond; Methylation; mRNA processing; mRNA splicing; mRNA transport; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 372 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:HGNC.
 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005654; C:nucleoplasm; IDA:HGNC.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003697; F:single-stranded DNA binding; IDA:HGNC.
 GO:0003727; F:single-stranded RNA binding; IC:HGNC.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0051170; P:nuclear import; IDA:HGNC.
 GO:0006405; P:RNA export from nucleus; IC:HGNC.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS