CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007619
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 U3 small nucleolar RNA-associated protein 10 
Protein Synonyms/Alias
 U3 snoRNA-associated protein 10; U three protein 10; U3 protein 10 required for transcription; t-UTP10 
Gene Name
 UTP10 
Gene Synonyms/Alias
 YJL109C; J0808 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
346EDKPVCDKFITSYTRacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). Involved in ribosome biosynthesis. 
Sequence Annotation
 REPEAT 1729 1767 HEAT.  
Keyword
 Complete proteome; Mitochondrion; Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; rRNA processing; Transcription. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1769 AA 
Protein Sequence
MSSLSDQLAQ VASNNATVAL DRKRRQKLHS ASLIYNSKTA ATQDYDFIFE NASKALEELS 60
QIEPKFAIFS RTLFSESSIS LDRNVQTKEE IKDLDNAINA YLLLASSKWY LAPTLHATEW 120
LVRRFQIHVK NTEMLLLSTL NYYQTPVFKR ILSIIKLPPL FNCLSNFVRS EKPPTALTMI 180
KLFNDMDFLK LYTSYLDQCI KHNATYTNQL LFTTCCFINV VAFNSNNDEK LNQLVPILLE 240
ISAKLLASKS KDCQIAAHTI LVVFATALPL KKTIILAAME TILSNLDAKE AKHSALLTIC 300
KLFQTLKGQG NVDQLPSKIF KLFDSKFDTV SILTFLDKED KPVCDKFITS YTRSIARYDR 360
SKLNIILSLL KKIRLERYEV RLIITDLIYL SEILEDKSQL VELFEYFISI NEDLVLKCLK 420
SLGLTGELFE IRLTTSLFTN ADVNTDIVKQ LSDPVETTKK DTASFQTFLD KHSELINTTN 480
VSMLTETGER YKKVLSLFTE AIGKGYKASS FLTSFFTTLE SRITFLLRVT ISPAAPTALK 540
LISLNNIAKY INSIEKEVNI FTLVPCLICA LRDASIKVRT GVKKILSLIA KRPSTKHYFL 600
SDKLYGENVT IPMLNPKDSE AWLSGFLNEY VTENYDISRI LTPKRNEKVF LMFWANQALL 660
IPSPYAKTVL LDNLNKSPTY ASSYSSLFEE FISHYLENRS SWEKSCIANK TNFEHFERSL 720
VNLVSPKEKQ SFMIDFVLSA LNSDYEQLAN IAAERLISIF ASLNNAQKLK IVQNIVDSSS 780
NVESSYDTVG VLQSLPLDSD IFVSILNQNS ISNEMDQTDF SKRRRRRSST SKNAFLKEEV 840
SQLAELHLRK LTIILEALDK VRNVGSEKLL FTLLSLLSDL ETLDQDGGLP VLYAQETLIS 900
CTLNTITYLK EHGCTELTNV RADILVSAIR NSASPQVQNK LLLVIGSLAT LSSEVILHSV 960
MPIFTFMGAH SIRQDDEFTT KVVERTILTV VPALIKNSKG NEKEEMEFLL LSFTTALQHV 1020
PRHRRVKLFS TLIKTLDPVK ALGSFLFLIA QQYSSALVNF KIGEARILIE FIKALLVDLH 1080
VNEELSGLND LLDIIKLLTS SKSSSEKKKS LESRVLFSNG VLNFSESEFL TFMNNTFEFI 1140
NKITEETDQD YYDVRRNLRL KVYSVLLDET SDKKLIRNIR EEFGTLLEGV LFFINSVELT 1200
FSCITSQENE EASDSETSLS DHTTEIKEIL FKVLGNVLQI LPVDEFVNAV LPLLSTSTNE 1260
DIRYHLTLVI GSKFELEGSE AIPIVNNVMK VLLDRMPLES KSVVISQVIL NTMTALVSKY 1320
GKKLEGSILT QALTLATEKV SSDMTEVKIS SLALITNCVQ VLGVKSIAFY PKIVPPSIKL 1380
FDASLADSSN PLKEQLQVAI LLLFAGLIKR IPSFLMSNIL DVLHVIYFSR EVDSSIRLSV 1440
ISLIIENIDL KEVLKVLFRI WSTEIATSND TVAVSLFLST LESTVENIDK KSATSQSPIF 1500
FKLLLSLFEF RSISSFDNNT ISRIEASVHE ISNSYVLKMN DKVFRPLFVI LVRWAFDGEG 1560
VTNAGITETE RLLAFFKFFN KLQENLRGII TSYFTYLLEP VDMLLKRFIS KDMENVNLRR 1620
LVINSLTSSL KFDRDEYWKS TSRFELISVS LVNQLSNIEN SIGKYLVKAI GALASNNSGV 1680
DEHNQILNKL IVEHMKASCS SNEKLWAIRA MKLIYSKIGE SWLVLLPQLV PVIAELLEDD 1740
DEEIEREVRT GLVKVVENVL GEPFDRYLD 1769 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0030688; C:preribosome, small subunit precursor; IDA:SGD.
 GO:0033553; C:rDNA heterochromatin; IDA:SGD.
 GO:0032040; C:small-subunit processome; IDA:SGD.
 GO:0034455; C:t-UTP complex; IDA:SGD.
 GO:0030515; F:snoRNA binding; IPI:SGD.
 GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR012954; BP28_C_dom.
 IPR021133; HEAT_type_2.
 IPR022125; U3snoRNP10. 
Pfam
 PF08146; BP28CT
 PF12397; U3snoRNP10 
SMART
 SM01036; BP28CT 
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS