UniProt Accession

 D3YWM4_MOUSE; D3YWM4 

Genbank Protein ID

 AC144798; AC154499; AC169511 

Genbank Nucleotide ID

  

Protein Name

 Propionyl-CoA carboxylase alpha chain, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Pcca 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
55	SSVEYEPKEKVHVKM	acetylation	[1]
76	VGPAPTSKSYLNMDA	acetylation	[2]
76	VGPAPTSKSYLNMDA	succinylation	[2]
89	DAIMEAIKKTRAQAV	acetylation	[3]
107	YGFLSENKEFAKRLA	acetylation	[1, 2, 3, 4]
107	YGFLSENKEFAKRLA	succinylation	[2]
111	SENKEFAKRLAAEDV	acetylation	[1]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

  

Sequence Annotation

  

Keyword

 Biotin; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 132 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004075; F:biotin carboxylase activity; IEA:InterPro.
 GO:0004658; F:propionyl-CoA carboxylase activity; IMP:MGI. 

Interpro

 IPR011764; Biotin_carboxylation_dom.
 IPR005481; CarbamoylP_synth_lsu_N.
 IPR016185; PreATP-grasp_dom. 

Pfam

 PF00289; CPSase_L_chain 

SMART

  

PROSITE

 PS50979; BC 

PRINTS