UniProt Accession

 SIA4C_HUMAN; Q11206; A8K6B2; O60497; Q8N6A6; Q8NFG7; Q96QQ9 

Genbank Protein ID

 L23767; X74570; AF516603; AF516604; AY040826; AK291577; AP000806; AP001318; BC010645; AF035249 

Genbank Nucleotide ID

 AAA16460.1; CAA52662.1; AAM66432.1; AAM66433.1; AAK93790.1; BAF84266.1; AAH10645.1; AAC14162.1 

Protein Name

 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 

Protein Synonyms/Alias

 Alpha 2,3-ST 4; Beta-galactoside alpha-2,3-sialyltransferase 4; Alpha 2,3-sialyltransferase IV; Gal-NAc6S; Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase; SAT-3; ST-4; ST3Gal IV; ST3GalIV; ST3GalA.2; STZ; Sialyltransferase 4C; SIAT4-C 

Gene Name

 ST3GAL4 

Gene Synonyms/Alias

 CGS23; NANTA3; SIAT4C; STZ 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
97	YELPYGTKGSEDLLL	ubiquitination	[1]
146	SLGDAINKYDVVIRL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 It may catalyze the formation of the NeuAc-alpha-2,3- Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3- galactosyl derivative. 

Sequence Annotation

 CARBOHYD 61 61 N-linked (GlcNAc...) (Potential).
 CARBOHYD 131 131 N-linked (GlcNAc...) (Potential).
 CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).
 CARBOHYD 329 329 N-linked (GlcNAc...) (Potential).
 DISULFID 120 273 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane; Reference proteome; Secreted; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0030173; C:integral to Golgi membrane; IEA:InterPro.
 GO:0003836; F:beta-galactoside (CMP) alpha-2,3-sialyltransferase activity; TAS:ProtInc.
 GO:0047288; F:monosialoganglioside sialyltransferase activity; IEA:Compara.
 GO:0018146; P:keratan sulfate biosynthetic process; TAS:Reactome.
 GO:0016266; P:O-glycan processing; TAS:Reactome.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome. 

Interpro

 IPR001675; Glyco_trans_29.
 IPR012163; Sialyl_trans. 

Pfam

 PF00777; Glyco_transf_29 

SMART

  

PROSITE

  

PRINTS