CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010848
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AMP deaminase 3 
Protein Synonyms/Alias
 AMP deaminase isoform E; Erythrocyte AMP deaminase 
Gene Name
 AMPD3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
432ARELEESKYQYSEPRubiquitination[1]
713LSHQEKQKFLGQNYYubiquitination[2]
721FLGQNYYKEGPEGNDubiquitination[1, 2]
731PEGNDIRKTNVAQIRubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 AMP deaminase plays a critical role in energy metabolism. 
Sequence Annotation
 REGION 388 393 Substrate binding (By similarity).
 REGION 664 667 Substrate binding (By similarity).
 ACT_SITE 608 608 Proton acceptor (By similarity).
 METAL 317 317 Zinc; catalytic (By similarity).
 METAL 319 319 Zinc; catalytic (By similarity).
 METAL 586 586 Zinc; catalytic (By similarity).
 METAL 663 663 Zinc; catalytic (By similarity).
 BINDING 319 319 Substrate (By similarity).
 BINDING 589 589 Substrate (By similarity).
 MOD_RES 107 107 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Hydrolase; Metal-binding; Nucleotide metabolism; Phosphoprotein; Polymorphism; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 767 AA 
Protein Sequence
MPRQFPKLNI SEVDEQVRLL AEKVFAKVLR EEDSKDALSL FTVPEDCPIG QKEAKERELQ 60
KELAEQKSVE TAKRKKSFKM IRSQSLSLQM PPQQDWKGPP AASPAMSPTT PVVTGATSLP 120
TPAPYAMPEF QRVTISGDYC AGITLEDYEQ AAKSLAKALM IREKYARLAY HRFPRITSQY 180
LGHPRADTAP PEEGLPDFHP PPLPQEDPYC LDDAPPNLDY LVHMQGGILF VYDNKKMLEH 240
QEPHSLPYPD LETYTVDMSH ILALITDGPT KTYCHRRLNF LESKFSLHEM LNEMSEFKEL 300
KSNPHRDFYN VRKVDTHIHA AACMNQKHLL RFIKHTYQTE PDRTVAEKRG RKITLRQVFD 360
GLHMDPYDLT VDSLDVHAGR QTFHRFDKFN SKYNPVGASE LRDLYLKTEN YLGGEYFARM 420
VKEVARELEE SKYQYSEPRL SIYGRSPEEW PNLAYWFIQH KVYSPNMRWI IQVPRIYDIF 480
RSKKLLPNFG KMLENIFLPL FKATINPQDH RELHLFLKYV TGFDSVDDES KHSDHMFSDK 540
SPNPDVWTSE QNPPYSYYLY YMYANIMVLN NLRRERGLST FLFRPHCGEA GSITHLVSAF 600
LTADNISHGL LLKKSPVLQY LYYLAQIPIA MSPLSNNSLF LEYSKNPLRE FLHKGLHVSL 660
STDDPMQFHY TKEALMEEYA IAAQVWKLST CDLCEIARNS VLQSGLSHQE KQKFLGQNYY 720
KEGPEGNDIR KTNVAQIRMA FRYETLCNEL SFLSDAMKSE EITALTN 767 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0003876; F:AMP deaminase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006196; P:AMP catabolic process; TAS:ProtInc.
 GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
 GO:0006144; P:purine nucleobase metabolic process; TAS:Reactome.
 GO:0043101; P:purine-containing compound salvage; TAS:Reactome. 
Interpro
 IPR006650; A/AMP_deam_AS.
 IPR001365; A/AMP_deaminase_dom.
 IPR006329; AMP_deaminase. 
Pfam
 PF00962; A_deaminase 
SMART
  
PROSITE
 PS00485; A_DEAMINASE 
PRINTS