CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026212
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dynamin-binding protein 
Protein Synonyms/Alias
  
Gene Name
 DNMBP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
286GWLEGSLKGRTGIFPubiquitination[1, 2]
561QQLIEFEKSLAGPGTubiquitination[1, 2]
594DIVRGSSKLITEQELubiquitination[1]
722LNLMLEEKQDESSRAubiquitination[2, 3]
1033NRVSSHLKHLTGFAPubiquitination[2]
1043TGFAPQIKDEVFEETubiquitination[1, 2]
1052EVFEETEKNFRMQERubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1601 AA 
Protein Sequence
MEAGSVVRAI FDFCPSVSEE LPLFVGDIIE VLAVVDEFWL LGKKEDVTGQ FPSSFVEIVT 60
IPSLKEGERL FVCICEFTSQ ELDNLPLHRG DLVILDGIPT AGWLQGRSCW GARGFFPSSC 120
VRELCLSSQS RQWHSQSALF QIPEYSMGQA RALMGLSAQL DEELDFREGD VITIIGVPEP 180
GWFEGELEGR RGIFPEGFVE LLGPLRTVDE SVSSGNQDDC IVNGEVDTPV GEEEIGPDED 240
EEEPGTYGVA LYRFQALEPN ELDFEVGDKI RILATLEDGW LEGSLKGRTG IFPYRFVKLC 300
PDTRVEETMA LPQEGSLARI PETSLDCLEN TLGVEEQRHE TSDHEAEEPD CIISEAPTSP 360
LGHLTSEYDT DRNSYQDEDT AGGPPRSPGV EWEMPLATDS PTSDPTEVVN GISSQPQVPF 420
HPNLQKSQYY STVGGSHPHS EQYPDLLPLE ARTRDYASLP PKRMYSQLKT LQKPVLPLYR 480
GSSVSASRVV KPRQSSPQLH NLASYTKKHH TSSVYSISER LEMKPGPQAQ GLVMEAATHS 540
QGDGSTDLDS KLTQQLIEFE KSLAGPGTEP DKILRHFSIM DFNSEKDIVR GSSKLITEQE 600
LPERRKALRP PPPRPCTPVS TSPHLLVDQN LKPAPPLVVR PSRPAPLPPS AQQRTNAVSP 660
KLLSRHRPTC ETLEKEGPGH MGRSLDQTSP CPLVLVRIEE MERDLDMYSR AQEELNLMLE 720
EKQDESSRAE TLEDLKFCES NIESLNMELQ QLREMTLLSS QSSSLVAPSG SVSAENPEQR 780
MLEKRAKVIE ELLQTERDYI RDLEMCIERI MVPMQQAQVP NIDFEGLFGN MQMVIKVSKQ 840
LLAALEISDA VGPVFLGHRD ELEGTYKIYC QNHDEAIALL EIYEKDEKIQ KHLQDSLADL 900
KSLYNEWGCT NYINLGSFLI KPVQRVMRYP LLLMELLNST PESHPDKVPL TNAVLAVKEI 960
NVNINEYKRR KDLGKNSIIA EKEYAHAEES AFLTYSLVLK YRKGDEDSLM EKISKLNIHS 1020
IIKKSNRVSS HLKHLTGFAP QIKDEVFEET EKNFRMQERL IKSFIRDLSL YLQHIRESAC 1080
VKVVAAVSMW DVCMERGHRD LEQFERVHRY ISDQLFTNFK ERTERLVISP LNQLLSMFTG 1140
PHKLVQKRFD KLLDFYNCTE RAEKLKDKKT LEELQSARNN YEALNAQLLD ELPKFHQYAQ 1200
GLFTNCVHGY AEAHCDFVHQ ALEQLKPLLS LLKVAGREGN LIAIFHEEHS RVLQQLQVFT 1260
FFPESLPATK KPFERKTIDR QSARKPLLGL PSYMLQSEEL RASLLARYPP EKLFQAERNF 1320
NAAQDLDVSL LEGDLVGVIK KKDPMGSQNR WLIDNGVTKG FVYSSFLKPY NPRRSHSDAS 1380
VGSHSSTESE HGSSSPRFPR QNSGSTLTFN PSSMAVSFTS GSCQKQPQDA SPPPKECDQG 1440
TLSASLNPSN SESSPSRCPS DPDSTSQPRS GDSADVARDV KQPTATPRSY RNFRHPEIVG 1500
YSVPGRNGQS QDLVKGCART AQAPEDRSTE PDGSEAEGNQ VYFAVYTFKA RNPNELSVSA 1560
NQKLKILEFK DVTGNTEWWL AEVNGKKGYV PSNYIRKTEY T 1601 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR027267; AH/BAR-dom.
 IPR004148; BAR_dom.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR000108; p67phox.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF03114; BAR
 PF00621; RhoGEF
 PF00018; SH3_1
 PF07653; SH3_2 
SMART
 SM00721; BAR
 SM00325; RhoGEF
 SM00326; SH3 
PROSITE
 PS51021; BAR
 PS00741; DH_1
 PS50010; DH_2
 PS50002; SH3 
PRINTS
 PR00499; P67PHOX.