CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010622
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neuropilin-1 
Protein Synonyms/Alias
 A5 protein; CD304 
Gene Name
 Nrp1 
Gene Synonyms/Alias
 Nrp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
908FELVDGVKLKKDKLNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity). 
Sequence Annotation
 DOMAIN 27 141 CUB 1.
 DOMAIN 147 265 CUB 2.
 DOMAIN 275 424 F5/8 type C 1.
 DOMAIN 431 583 F5/8 type C 2.
 DOMAIN 645 811 MAM.
 METAL 195 195 Calcium (By similarity).
 METAL 209 209 Calcium (By similarity).
 METAL 250 250 Calcium (By similarity).
 CARBOHYD 150 150 N-linked (GlcNAc...) (Potential).
 CARBOHYD 261 261 N-linked (GlcNAc...).
 CARBOHYD 300 300 N-linked (GlcNAc...) (Potential).
 CARBOHYD 522 522 N-linked (GlcNAc...).
 CARBOHYD 612 612 O-linked (Xyl...) (chondroitin sulfate);
 CARBOHYD 612 612 O-linked (Xyl...) (heparan sulfate);
 CARBOHYD 842 842 N-linked (GlcNAc...) (Potential).
 DISULFID 27 54 Probable.
 DISULFID 82 104 Probable.
 DISULFID 147 173 By similarity.
 DISULFID 206 228 By similarity.
 DISULFID 275 424 By similarity.
 DISULFID 431 583 By similarity.  
Keyword
 3D-structure; Angiogenesis; Calcium; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Heparan sulfate; Heparin-binding; Membrane; Metal-binding; Neurogenesis; Proteoglycan; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 923 AA 
Protein Sequence
MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP SEKCEWLIQA 60
PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW GKFCGKIAPS PVVSSGPFLF 120
IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTAPTGVIKS PGFPEKYPNS LECTYIIFAP 180
KMSEIILEFE SFDLEQDSNP PGGMFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS 240
GVLSMVFYTD SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN 300
WSVERSRLNY PENGWTPGED SYKEWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYRV 360
DISSNGEDWI SLKEGNKAII FQGNTNPTDV VLGVFSKPLI TRFVRIKPVS WETGISMRFE 420
VYGCKITDYP CSGMLGMVSG LISDSQITAS NQADRNWMPE NIRLVTSRTG WALPPSPHPY 480
TNEWLQVDLG DEKIVRGVII QGGKHRENKV FMRKFKIAYS NNGSDWKTIM DDSKRKAKSF 540
EGNNNYDTPE LRTFSPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEAPTA GPTTPNGNPV 600
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC EFGWGSHKTF 660
CHWEHDSHAQ LRWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQSSAH 720
CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI 780
FEGEIGKGNL GGIAVDDISI NNHISQEDCA KPTDLDKKNT EIKIDETGST PGYEGEGEGD 840
KNISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 900
FELVDGVKLK KDKLNPQSNY SEA 923 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005883; C:neurofilament; IDA:MGI.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0017154; F:semaphorin receptor activity; IGI:MGI.
 GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:Compara.
 GO:0007411; P:axon guidance; IDA:MGI.
 GO:0007413; P:axonal fasciculation; IMP:MGI.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0016477; P:cell migration; IMP:MGI.
 GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Compara.
 GO:0016358; P:dendrite development; IMP:MGI.
 GO:0060666; P:dichotomous subdivision of terminal units involved in salivary gland branching; IMP:MGI.
 GO:0035767; P:endothelial cell chemotaxis; IEA:Compara.
 GO:0007507; P:heart development; IGI:MGI.
 GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IEA:Compara.
 GO:0048843; P:negative regulation of axon extension involved in axon guidance; IDA:MGI.
 GO:0009887; P:organ morphogenesis; IEA:InterPro.
 GO:0001569; P:patterning of blood vessels; IMP:MGI.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0048485; P:sympathetic nervous system development; IMP:MGI.
 GO:0021636; P:trigeminal nerve morphogenesis; IMP:MGI.
 GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IMP:MGI. 
Interpro
 IPR000421; Coagulation_fac_5/8-C_type_dom.
 IPR008985; ConA-like_lec_gl_sf.
 IPR000859; CUB_dom.
 IPR008979; Galactose-bd-like.
 IPR000998; MAM_dom.
 IPR014648; Neuropilin.
 IPR022579; Neuropilin1_C.
 IPR027146; NRP1. 
Pfam
 PF00431; CUB
 PF11980; DUF3481
 PF00754; F5_F8_type_C
 PF00629; MAM 
SMART
 SM00042; CUB
 SM00231; FA58C
 SM00137; MAM 
PROSITE
 PS01180; CUB
 PS01285; FA58C_1
 PS01286; FA58C_2
 PS50022; FA58C_3
 PS00740; MAM_1
 PS50060; MAM_2 
PRINTS
 PR00020; MAMDOMAIN.