CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016241
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat transmembrane neuronal protein 3 
Protein Synonyms/Alias
  
Gene Name
 LRRTM3 
Gene Synonyms/Alias
 UNQ803/PRO1693 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
450KRYPASMKQLQQRSLacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system. 
Sequence Annotation
 DOMAIN 31 61 LRRNT.
 REPEAT 63 83 LRR 1.
 REPEAT 86 107 LRR 2.
 REPEAT 110 131 LRR 3.
 REPEAT 134 155 LRR 4.
 REPEAT 158 179 LRR 5.
 REPEAT 182 203 LRR 6.
 REPEAT 206 226 LRR 7.
 REPEAT 230 251 LRR 8.
 REPEAT 254 275 LRR 9.
 REPEAT 279 300 LRR 10.
 DOMAIN 312 363 LRRCT.
 CARBOHYD 126 126 N-linked (GlcNAc...) (Potential).
 CARBOHYD 357 357 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane; Postsynaptic cell membrane; Reference proteome; Repeat; Signal; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 581 AA 
Protein Sequence
MGFNVIRLLS GSAVALVIAP TVLLTMLSSA ERGCPKGCRC EGKMVYCESQ KLQEIPSSIS 60
AGCLGLSLRY NSLQKLKYNQ FKGLNQLTWL YLDHNHISNI DENAFNGIRR LKELILSSNR 120
ISYFLNNTFR PVTNLRNLDL SYNQLHSLGS EQFRGLRKLL SLHLRSNSLR TIPVRIFQDC 180
RNLELLDLGY NRIRSLARNV FAGMIRLKEL HLEHNQFSKL NLALFPRLVS LQNLYLQWNK 240
ISVIGQTMSW TWSSLQRLDL SGNEIEAFSG PSVFQCVPNL QRLNLDSNKL TFIGQEILDS 300
WISLNDISLA GNIWECSRNI CSLVNWLKSF KGLRENTIIC ASPKELQGVN VIDAVKNYSI 360
CGKSTTERFD LARALPKPTF KPKLPRPKHE SKPPLPPTVG ATEPGPETDA DAEHISFHKI 420
IAGSVALFLS VLVILLVIYV SWKRYPASMK QLQQRSLMRR HRKKKRQSLK QMTPSTQEFY 480
VDYKPTNTET SEMLLNGTGP CTYNKSGSRE CEIPLSMNVS TFLAYDQPTI SYCGVHHELL 540
SHKSFETNAQ EDTMETHLET ELDLSTITTA GRISDHKQQL A 581 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:1902004; P:positive regulation of beta-amyloid formation; IMP:MGI. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 
Pfam
 PF01462; LRRNT 
SMART
 SM00369; LRR_TYP
 SM00013; LRRNT 
PROSITE
 PS51450; LRR 
PRINTS