UniProt Accession

 COG4_HUMAN; Q9H9E3; B4DMN8; C9JS23; Q96D40; Q9BRF0; Q9BVZ2; Q9H5Y4; Q9Y3W3 

Genbank Protein ID

 AB088369; AK022874; AK026435; AK297557; AC106804; BC000796; BC006306; BC013347; BC072438; AL050101 

Genbank Nucleotide ID

 BAC05682.1; BAB14286.1; BAB15483.1; BAG59950.1; AAH00796.1; AAH06306.2; AAH13347.2; AAH72438.1; CAB43272.1 

Protein Name

 Conserved oligomeric Golgi complex subunit 4 

Protein Synonyms/Alias

 COG complex subunit 4; Component of oligomeric Golgi complex 4 

Gene Name

 COG4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	QQNTIESKMVTLHRM	ubiquitination	[1, 2, 3]
166	HRYLCLDKSVIELSR	ubiquitination	[2]
176	IELSRQGKEGSMIDA	ubiquitination	[2, 4]
186	SMIDANLKLLQEAEQ	ubiquitination	[2]
208	EKFAIATKEGDLPQV	ubiquitination	[2, 4]
234	LHEEGLRKFSEYLCK	ubiquitination	[2]
320	QVEKVVDKFIKQRDY	ubiquitination	[2]
323	KVVDKFIKQRDYHQQ	ubiquitination	[2]
346	MRNSTTEKIEPRELD	ubiquitination	[2, 4]
393	SMASEEVKQEHQKCL	ubiquitination	[2]
443	VALDTYEKGQLTSSM	acetylation	[5]
532	QQGKFDTKGIESTDE	ubiquitination	[2, 4]
571	TLESDCTKLFSQGIG	ubiquitination	[2]
706	LGGLQFDKELRSLIA	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. 

Sequence Annotation

 REGION 2 84 Interacts with SCFD1.
 REGION 85 153 Interacts with STX5.
 REGION 618 740 D domain.
 REGION 741 785 E domain; essential for proper cell
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Congenital disorder of glycosylation; Disease mutation; Golgi apparatus; Membrane; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 785 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0017119; C:Golgi transport complex; IDA:UniProtKB.
 GO:0007030; P:Golgi organization; IMP:UniProtKB.
 GO:0048213; P:Golgi vesicle prefusion complex stabilization; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IMP:UniProtKB. 

Interpro

 IPR013167; COG_su4. 

Pfam

 PF08318; COG4 

SMART

 SM00762; Cog4 

PROSITE

  

PRINTS