UniProt Accession

 MT4_HUMAN; P47944; Q14DA1 

Genbank Protein ID

 U07807; AC026461; BC113442; BC113444 

Genbank Nucleotide ID

 AAA20232.1; AAI13443.1; AAI13445.1 

Protein Name

 Metallothionein-4 

Protein Synonyms/Alias

 MT-4; Metallothionein-IV; MT-IV 

Gene Name

 MT4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	CCPPGCAKCARGCIC	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia. 

Sequence Annotation

 METAL 6 6 Divalent metal cation; cluster B (By
 METAL 8 8 Divalent metal cation; cluster B (By
 METAL 14 14 Divalent metal cation; cluster B (By
 METAL 16 16 Divalent metal cation; cluster B (By
 METAL 20 20 Divalent metal cation; cluster B (By
 METAL 22 22 Divalent metal cation; cluster B (By
 METAL 25 25 Divalent metal cation; cluster B (By
 METAL 27 27 Divalent metal cation; cluster B (By
 METAL 30 30 Divalent metal cation; cluster B (By
 METAL 34 34 Divalent metal cation; cluster A (By
 METAL 35 35 Divalent metal cation; cluster A (By
 METAL 37 37 Divalent metal cation; cluster A (By
 METAL 38 38 Divalent metal cation; cluster A (By
 METAL 42 42 Divalent metal cation; cluster A (By
 METAL 45 45 Divalent metal cation; cluster A (By
 METAL 49 49 Divalent metal cation; cluster A (By
 METAL 51 51 Divalent metal cation; cluster A (By
 METAL 58 58 Divalent metal cation; cluster A (By
 METAL 60 60 Divalent metal cation; cluster A (By
 METAL 61 61 Divalent metal cation; cluster A (By  

Keyword

 Complete proteome; Copper; Metal-binding; Metal-thiolate cluster; Polymorphism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 62 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0005507; F:copper ion binding; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; NAS:UniProtKB.
 GO:0006875; P:cellular metal ion homeostasis; IEA:Compara. 

Interpro

 IPR017854; Metalthion_dom.
 IPR023587; Metalthion_dom_vert.
 IPR003019; Metalthion_sfam_euk.
 IPR000006; Metalthion_vert. 

Pfam

 PF00131; Metallothio 

SMART

  

PROSITE

 PS00203; METALLOTHIONEIN_VRT 

PRINTS

 PR00860; MTVERTEBRATE.