CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017327
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrobin 
Protein Synonyms/Alias
 Centrosomal BRCA2-interacting protein; LYST-interacting protein 8 
Gene Name
 CNTROB 
Gene Synonyms/Alias
 LIP8; PP1221 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88VGLEKNLKKKDGSKHubiquitination[1]
227VAVAADRKKDTMIEQubiquitination[1]
610PPMAVALKPVLQQSRubiquitination[1]
698PDGEGLLKQGLPPAQubiquitination[1]
761PPPVHKTKVPLAMASubiquitination[1, 2]
832EDLLLYLKRLEHSGYubiquitination[1, 2]
883RLGEIPRKEIPSQAVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. 
Sequence Annotation
 REGION 365 903 Required for centrosome localization.  
Keyword
 Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 903 AA 
Protein Sequence
MATSADSPSS PLGAEDLLSD SSEPPGLNQV SSEVTSQLYA SLRLSRQAEA TARAQLYLPS 60
TSPPHEGLDG FAQELSRSLS VGLEKNLKKK DGSKHIFEME SVRGQLQTML QTSRDTAYRD 120
PLIPGAGSER REEDSFDSDS TATLLNTRPL QDLSPSSSAQ ALEELFPRYT SLRPGPPLNP 180
PDFQGLRDAL DSEHTRRKHC ERHIQSLQTR VLELQQQLAV AVAADRKKDT MIEQLDKTLA 240
RVVEGWNRHE AERTEVLRGL QEEHQAAELT RSKQQETVTR LEQSLSEAME ALNREQESAR 300
LQQRERETLE EERQALTLRL EAEQQRCCVL QEERDAARAG QLSEHRELET LRAALEEERQ 360
TWAQQEHQLK EHYQALQEES QAQLEREKEK SQREAQAAWE TQHQLALVQS EVRRLEGELD 420
TARRERDALQ LEMSLVQARY ESQRIQLESE LAVQLEQRVT ERLAQAQESS LRQAASLREH 480
HRKQLQDLSG QHQQELASQL AQFKVEMAER EERQQQVAED YELRLAREQA RVCELQSGNQ 540
QLEEQRVELV ERLQAMLQAH WDEANQLLST TLPPPNPPAP PAGPSSPGPQ EPEKEERRVW 600
TMPPMAVALK PVLQQSREAR DELPGAPPVL CSSSSDLSLL LGPSFQSQHS FQPLEPKPDL 660
TSSTAGAFSA LGAFHPDHRA ERPFPEEDPG PDGEGLLKQG LPPAQLEGLK NFLHQLLETV 720
PQNNENPSVD LLPPKSGPLT VPSWEEAPQV PRIPPPVHKT KVPLAMASSL FRVPEPPSSH 780
SQGSGPSSGS PERGGDGLTF PRQLMEVSQL LRLYQARGWG ALPAEDLLLY LKRLEHSGYK 840
PGRKEEGFSG WKLDYGEWSG TDGRGDNVPR RNTDSRLGEI PRKEIPSQAV PRRLATAPKT 900
EKPPARKKSG HPAPSSMRSR GGVWR 925 
Gene Ontology
 GO:0005814; C:centriole; IDA:HGNC.
 GO:0007099; P:centriole replication; IMP:HGNC.
 GO:0051299; P:centrosome separation; IMP:HGNC.
 GO:0000910; P:cytokinesis; IMP:HGNC. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS