CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015739
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein RUFY3 
Protein Synonyms/Alias
 Rap2-interacting protein x; RIPx; Single axon-regulated protein; Singar 
Gene Name
 RUFY3 
Gene Synonyms/Alias
 KIAA0871 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
157VKDLPGLKTPVGRGRubiquitination[1]
420QSSDLGVKQKSELNSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). 
Sequence Annotation
 DOMAIN 95 227 RUN.  
Keyword
 Alternative splicing; Cell projection; Coiled coil; Complete proteome; Developmental protein; Differentiation; Neurogenesis; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 469 AA 
Protein Sequence
MSALTPPTDM PTPTTDKITQ AAMETIYLCK FRVSMDGEWL CLRELDDISL TPDPEPTHED 60
PNYLMANERM NLMNMAKLSI KGLIESALNL GRTLDSDYAP LQQFFVVMEH CLKHGLKAKK 120
TFLGQNKSFW GPLELVEKLV PEAAEITASV KDLPGLKTPV GRGRAWLRLA LMQKKLSEYM 180
KALINKKELL SEFYEPNALM MEEEGAIIAG LLVGLNVIDA NFCMKGEDLD SQVGVIDFSM 240
YLKDGNSSKG TEGDGQITAI LDQKNYVEEL NRHLNATVNN LQAKVDALEK SNTKLTEELA 300
VANNRIITLQ EEMERVKEES SYILESNRKG PKQDRTAEGQ ALSEARKHLK EETQLRLDVE 360
KELEMQISMR QEMELAMKML EKDVCEKQDA LVSLRQQLDD LRALKHELAF KLQSSDLGVK 420
QKSELNSRLE EKTNQMAATI KQLEQRLRQA ERSRQSAELD NRLFKQDFGD KINSLQLEVE 480
ELTRQRNQLE LELKQEKERR LQNDRSIPGR GSQKSESKMD GKHKMQEENV KLKKPLEESH 540
RLQPHPMDEQ DQLLLSEKPQ LCQLCQEDGS LTKNVCKNCS GTFCDACSTN ELPLPSSIKL 600
ERVCNPCHKH LMKQYSTSPS 620 
Gene Ontology
 GO:0030175; C:filopodium; ISS:HGNC.
 GO:0030426; C:growth cone; ISS:HGNC.
 GO:0050771; P:negative regulation of axonogenesis; ISS:HGNC. 
Interpro
 IPR004012; Run. 
Pfam
 PF02759; RUN 
SMART
 SM00593; RUN 
PROSITE
 PS50826; RUN 
PRINTS