| Tag | Content |
|---|
| CPLM ID | CPLM-016677 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NEDD4-like E3 ubiquitin-protein ligase WWP1 |
Protein Synonyms/Alias | WW domain-containing protein 1 |
Gene Name | Wwp1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 324 | RNNSVFDKVRQPEGC | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF (By similarity). Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT- 1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. |
Sequence Annotation | DOMAIN 5 98 C2.
DOMAIN 345 378 WW 1.
DOMAIN 377 410 WW 2.
DOMAIN 452 485 WW 3.
DOMAIN 492 525 WW 4.
DOMAIN 584 918 HECT.
REGION 345 525 Interaction with ERBB4.
ACT_SITE 886 886 Glycyl thioester intermediate (By |
Keyword | Cell membrane; Complete proteome; Cytoplasm; Ligase; Membrane; Nucleus; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 918 AA |
Protein Sequence | MATASPRSDT SDIHSGRLQL KVTVSSAKLK RKKNWFGTAI YTEVIVDGEV KKTAKSSSSS 60
NPKWDEQLIV NVTPQTTLEF RVWSHHTLKA DALLGKATVD LKQVLLTHNR KLEKVKEQLK 120
LSLENKNGIV QTGELTVVLD GLVIEQEPVT NRSSSPPIEI QQNGDALHEN GDPATRTTPR 180
LPVEGTIGID NHVSTNTVVP NSCCSHVVNG ENTPSSPSQV AARPKNAPAP KPVTSAPTSD 240
TVNGESSSVL ADNTSTMGTL LPSEDTTSTS NCTSTTTQEP PVQEPPASSE HSECIPSASA 300
EVGPEARSLI DPDSDSRNNS VFDKVRQPEG CVEPLRPQSG NTNTEALPSG WEQRKDPHGR 360
TYYVDHNTRT TTWERPQPLP PGWERRVDDR GRVYYVDHNT RTTTWQRPTM ESVRNFEQWQ 420
SQRNQLQGAM QQFNQRYLYS ASMLAAENDP YGPLPPGWEK RVDSTDRVYF VNHNTKTTQW 480
EDPRTQGLPN EEPLPEGWEI RYTREGVRYF VDHNTRTTTF KDPRNGKSSV TKGGPQIAYE 540
RSFRWKLAHF RYLCQSNALP SHVKINVSRQ TLFEDSFQQI MALKPYDLRR RLYVIFRGEE 600
GLDYGGLARE WFFLLSHEVL NPMYCLFEYA GKNNYCLQIN PASTINPDHL SYFCFIGRFI 660
AMALFHGKFI DTGFSLPFYK RMLSKKLTIK DLESIDTEFY NSLIWIRDNN IEECGLEMYF 720
SVDMEILGKV TSHDLKLGGS NILVTEENKD EYIGLMTEWR FSRGVQEQTK AFLDGFNEVV 780
PLQWLQYFDE KELEVMLCGM QEVDLADWQR NTVYRHYTRN SKQIIWFWQF VKETDNEVRM 840
RLLQFVTGTC RLPLGGFAEL MGSNGPQKFC IEKVGKDTWL PRSHTCFNRL DLPPYKSYEQ 900
LKEKLLFAIE ETEGFGQE 918 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0005634; C:nucleus; IBA:RefGenome. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. GO:0030324; P:lung development; TAS:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB. GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB. GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. GO:0030217; P:T cell differentiation; TAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |