| Tag | Content |
|---|
| CPLM ID | CPLM-006141 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein HIR1 |
Protein Synonyms/Alias | Histone transcription regulator 1 |
Gene Name | HIR1 |
Gene Synonyms/Alias | YBL008W; YBL0318 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 40 | ATGGLDGKIRIWSID | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA- binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1. |
Sequence Annotation | REPEAT 15 54 WD 1.
REPEAT 77 116 WD 2.
REPEAT 135 174 WD 3.
REPEAT 177 216 WD 4.
REPEAT 230 273 WD 5.
REPEAT 312 350 WD 6.
REPEAT 354 393 WD 7.
REPEAT 691 732 WD 8.
REPEAT 741 780 WD 9.
REPEAT 799 839 WD 10.
REGION 1 389 Mediates transcriptional repression.
REGION 304 840 Interaction with ASF1.
REGION 392 840 Mediates transcriptional repression,
MOD_RES 610 610 Phosphoserine. |
Keyword | Centromere; Chromatin regulator; Chromosome; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 840 AA |
Protein Sequence | MKVVKFPWLA HREESRKYEI YTVDVSHDGK RLATGGLDGK IRIWSIDSIL RCMELESLTP 60
EIPLPQDLQM PLCSMSRHTG SITCVKFSPD GKYLASGSDD RILLIWALDE EQSSQPAFGS 120
EHEREHWTVR KRLVAHDNDI QDICWAPDSS ILVTVGLDRS VIVWNGSTFE KLKRFDVHQS 180
LVKGVVFDPA NKYFATTSDD RTMKIFRYHK TGDISFTIEH IITEPFKESP LTTYFRRPSW 240
SPDGQHIAVP NATNGPVSSV AIVNRGTWDT NVSLIGHDAP TEVARFNPRL FERNAGVKQK 300
KDDDPENALV GQNDDKVHHF DKNIDSVVAT AGQDKSLAVW STSRPRPILV AFDIANKSIT 360
DMSWNPDGSL LFVASLDSSI TLFKFENNEL GKPIPLEKNM EQLYRYGVDK DSLDFPESIN 420
QLLLEDQTKS FKHTKISTSK LGENHPTLAT NSASNQKDNN DASVSRSEHI NILIPKRKKD 480
AILNKAVTLK SGKKRVAPTL ISTSSSSPFS NGIKKPTLDS KRIENNVKSS TKTINSKNTL 540
LNVPEGVEKK ISISSFPLPR LGIHSLIMGT KERSAWKISN SELENDDADN AGGKGSDGTS 600
NSIDDIAVLS EEENDFHRMT LNAKLTQEKI WSEEPTTRCL LQSDVIPDTD VVVLEGGSLD 660
DIAVLEIRNG VERSIQFDSE ALLDNPTRIL GYQGGKRTIE TFIPEVIICA IGSKDCKCWC 720
LASANGSIYI LSYNGQQRIP KICLGHKVIK MVTSSKYLLV LTERGLFFAW DLLDLKLVLR 780
NVPILPILNG QPIHGNKVRI NKVIKCFRLD GSSCDLLLEV GDPKNVYKWT KDLGCWSLYK 840 |
Gene Ontology | GO:0000775; C:chromosome, centromeric region; IDA:SGD. GO:0000417; C:HIR complex; IDA:SGD. GO:0005634; C:nucleus; IPI:SGD. GO:0003682; F:chromatin binding; IEA:InterPro. GO:0003714; F:transcription corepressor activity; IDA:SGD. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0006336; P:DNA replication-independent nucleosome assembly; IDA:SGD. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:SGD. GO:0006368; P:transcription elongation from RNA polymerase II promoter; IGI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |