CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002300
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calbindin 
Protein Synonyms/Alias
 Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type 
Gene Name
 CALB1 
Gene Synonyms/Alias
 CAB27 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
161FDSNNDGKLELTEMAubiquitination[1]
180VQENFLLKFQGIKMCubiquitination[1]
189QGIKMCGKEFNKAFEubiquitination[1]
193MCGKEFNKAFELYDQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. 
Sequence Annotation
 DOMAIN 11 46 EF-hand 1.
 DOMAIN 53 88 EF-hand 2.
 DOMAIN 98 133 EF-hand 3.
 DOMAIN 142 177 EF-hand 4.
 DOMAIN 186 221 EF-hand 5.
 REGION 2 7 Interaction with RANBP9.
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 Acetylation; Calcium; Complete proteome; Metal-binding; Reference proteome; Repeat; Vitamin D. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 261 AA 
Protein Sequence
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA GLELSPEMKT 60
FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET 120
EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK 180
FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA 240
LSDGGKLYRT DLALILCAGD N 261 
Gene Ontology
 GO:0030424; C:axon; ISS:BHF-UCL.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005509; F:calcium ion binding; TAS:ProtInc.
 GO:0005499; F:vitamin D binding; IEA:UniProtKB-KW.
 GO:0071310; P:cellular response to organic substance; IEA:Compara.
 GO:0007611; P:learning or memory; IEA:Compara.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0072205; P:metanephric collecting duct development; IEA:Compara.
 GO:0072286; P:metanephric connecting tubule development; IEA:Compara.
 GO:0072221; P:metanephric distal convoluted tubule development; IEA:Compara.
 GO:0035502; P:metanephric part of ureteric bud development; IEA:Compara.
 GO:0048167; P:regulation of synaptic plasticity; IEA:Compara.
 GO:0010842; P:retina layer formation; IEA:Compara. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF13405; EF_hand_4
 PF13499; EF_hand_5 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS