CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000681
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and BTB domain-containing protein 43 
Protein Synonyms/Alias
 Zinc finger and BTB domain-containing protein 22B; Zinc finger protein 297B; ZnF-x 
Gene Name
 ZBTB43 
Gene Synonyms/Alias
 KIAA0414; ZBTB22B; ZNF297B 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
22FSSTILQKLNQQRQQubiquitination[1]
65FCDQVLLKNSRRIVLubiquitination[1]
247HKRWIHVKPERLEQAacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 33 97 BTB.
 ZN_FING 373 394 C2H2-type 1; atypical.
 ZN_FING 400 422 C2H2-type 2.
 ZN_FING 428 450 C2H2-type 3; atypical.  
Keyword
 3D-structure; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 467 AA 
Protein Sequence
MEPGTNSFRV EFPDFSSTIL QKLNQQRQQG QLCDVSIVVQ GHIFRAHKAV LAASSPYFCD 60
QVLLKNSRRI VLPDVMNPRV FENILLSSYT GRLVMPAPEI VSYLTAASFL QMWHVVDKCT 120
EVLEGNPTVL CQKLNHGSDH QSPSSSSYNG LVESFELGSG GHTDFPKAQE LRDGENEEES 180
TKDELSSQLT EHEYLPSNSS TEHDRLSTEM ASQDGEEGAS DSAEFHYTRP MYSKPSIMAH 240
KRWIHVKPER LEQACEGMDV HATYDEHQVT ESINTVQTEH TVQPSGVEED FHIGEKKVEA 300
EFDEQADESN YDEQVDFYGS SMEEFSGERS DGNLIGHRQE AALAAGYSEN IEMVTGIKEE 360
ASHLGFSATD KLYPCQCGKS FTHKSQRDRH MSMHLGLRPY GCGVCGKKFK MKHHLVGHMK 420
IHTGIKPYEC NICAKRFMWR DSFHRHVTSC TKSYEAAKAE QNTTEAN 467 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS