CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004568
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Betaine aldehyde dehydrogenase 
Protein Synonyms/Alias
 BADH 
Gene Name
 betB 
Gene Synonyms/Alias
 b0312; JW0304 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
88ERNDELAKLETLDTGacetylation[1]
305CKAAFEQKILARVERacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
  
Sequence Annotation
 NP_BIND 229 234 NAD (By similarity).
 ACT_SITE 252 252 By similarity.
 ACT_SITE 286 286 By similarity.  
Keyword
 Complete proteome; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 490 AA 
Protein Sequence
MSRMAEQQLY IHGGYTSATS GRTFETINPA NGNVLATVQA AGREDVDRAV KSAQQGQKIW 60
ASMTAMERSR ILRRAVDILR ERNDELAKLE TLDTGKAYSE TSTVDIVTGA DVLEYYAGLI 120
PALEGSQIPL RETSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 180
TPLTALKLAE IYSEAGLPDG VFNVLPGVGA ETGQYLTEHP GIAKVSFTGG VASGKKVMAN 240
SAASSLKEVT MELGGKSPLI VFDDADLDLA ADIAMMANFF SSGQVCTNGT RVFVPAKCKA 300
AFEQKILARV ERIRAGDVFD PQTNFGPLVS FPHRDNVLRY IAKGKEEGAR VLCGGDVLKG 360
DGFDNGAWVA PTVFTDCSDD MTIVREEIFG PVMSILTYES EDEVIRRAND TDYGLAAGIV 420
TADLNRAHRV IHQLEAGICW INTWGESPAE MPVGGYKHSG IGRENGVMTL QSYTQVKSIQ 480
VEMAKFQSIF 490 
Gene Ontology
 GO:0008802; F:betaine-aldehyde dehydrogenase activity; IDA:EcoCyc.
 GO:0019285; P:glycine betaine biosynthetic process from choline; IDA:EcoCyc.
 GO:0006970; P:response to osmotic stress; IEP:EcoCyc. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR011264; Betaine_Ald_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS