CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018168
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box only protein 21 
Protein Synonyms/Alias
  
Gene Name
 Fbxo21 
Gene Synonyms/Alias
 Fbx21; Kiaa0875 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
74QSSGQVWKEQFRVRWubiquitination[1]
101VNWLEEYKVRQKAGLubiquitination[1]
119KIVASFSKRFFSEHVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity). 
Sequence Annotation
 DOMAIN 27 76 F-box.  
Keyword
 Alternative splicing; Complete proteome; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 627 AA 
Protein Sequence
MASVAGDSAM EVVPALAEEA AAEATGPSCL VQLPGEVLEY ILCSGSLTAL DIGRVSSTCR 60
RLREVCQSSG QVWKEQFRVR WPSLMKHYSP TDYVNWLEEY KVRQKAGLEA RKIVASFSKR 120
FFSEHVPCNG FSDIENLEGP EIFFEDELVC ILNMEGRKAL TWKYYAKKIL YYLRQQKILN 180
NLKAFLQQPD DYESYLEGAV YIDQYCNPLS DISFRDIQAQ IHSIVELVCK TLRGINSRHP 240
SLTFRAGESS MIMEIELQSQ VLDAINYVLY DQLKFKGNRM DYYNALNLYM HQVLTRRTGI 300
PISMSLLYLT VARQLGVPLE PVNFPSHFLL RWCQGAEGAT LDIFDYIYID AFGKGKQLTV 360
KECEYLIGQH VTAALYGVVN VKKVLQRMVG NLLSLGKREG IDQSYQLLRD SLDLYLAMYP 420
DQVQLLLLQA RLYFHLGIWP EKSFCLVLKV LDILQHIQTL DPGQHGAVGY LVQHTLEHIE 480
RKKEEVGVEV KLRSEEKHRD VCYSIGLVMK HKRYGYNCVI YGWDPTCMMG HEWIRNMNVH 540
SLPHGHHQPF YNVLVEDGSC RYAAQENLEY NVEPQEISHP DVGRYFSEFT GTHYIPNAEL 600
EIRYPEDLEF VYETVQNIYS AKEDTAE 627 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro. 
Interpro
 IPR001810; F-box_dom_cyclin-like.
 IPR011722; Hemimethylated_DNA-bd_dom. 
Pfam
 PF08755; YccV-like 
SMART
 SM00992; YccV-like 
PROSITE
 PS50181; FBOX 
PRINTS