UniProt Accession

 VPS29_HUMAN; Q9UBQ0; Q502Y5; Q6FIF8; Q6IAH3; Q9H0W0; Q9NRP1; Q9NRU7 

Genbank Protein ID

 AF193795; AF175264; AF168716; AF201936; AF201946; AL136614; CR457182; CR533468; BC000880; BC095446 

Genbank Nucleotide ID

 AAF04596.1; AAF89952.1; AAF87318.1; AAF86872.1; AAF17238.1; CAB66549.1; CAG33463.1; CAG38499.1; AAH00880.1; AAH95446.1 

Protein Name

 Vacuolar protein sorting-associated protein 29 

Protein Synonyms/Alias

 hVPS29; PEP11 homolog; Vesicle protein sorting 29 

Gene Name

 VPS29 

Gene Synonyms/Alias

 DC15; DC7; MDS007 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	RCNSLPAKFKKLLVP	ubiquitination	[1]
24	SLPAKFKKLLVPGKI	ubiquitination	[1]
30	KKLLVPGKIQHILCT	ubiquitination	[1]
43	CTGNLCTKESYDYLK	ubiquitination	[1]
50	KESYDYLKTLAGDVH	acetylation	[2]
50	KESYDYLKTLAGDVH	ubiquitination	[1, 3]
73	NLNYPEQKVVTVGQF	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). 

Sequence Annotation

 METAL 8 8 Zinc 1 (By similarity).
 METAL 10 10 Zinc 1 (By similarity).
 METAL 39 39 Zinc 1 (By similarity).
 METAL 39 39 Zinc 2 (By similarity).
 METAL 62 62 Zinc 2 (By similarity).
 METAL 86 86 Zinc 2 (By similarity).
 METAL 115 115 Zinc 2 (By similarity).
 METAL 117 117 Zinc 1 (By similarity).
 MOD_RES 50 50 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Endosome; Hydrolase; Membrane; Metal-binding; Protein transport; Reference proteome; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0005768; C:endosome; IDA:LIFEdb.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004647; F:phosphoserine phosphatase activity; IEA:EC.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR024654; Calcineurin-like_PEstase_dom.
 IPR000979; Phosphodiesterase_MJ0936. 

Pfam

 PF12850; Metallophos_2 

SMART

  

PROSITE

  

PRINTS