UniProt Accession

 FBX6_RAT; Q923V4; Q6P512 

Genbank Protein ID

 AF393484; BC063148 

Genbank Nucleotide ID

 AAK70899.1; AAH63148.1 

Protein Name

 F-box only protein 6 

Protein Synonyms/Alias

 F-box only protein 6b; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2 

Gene Name

 Fbxo6 

Gene Synonyms/Alias

 Fbg2; Fbs2; Fbxo6b 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
140	KSQMVDLKAEGYSEK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex- type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). 

Sequence Annotation

 DOMAIN 1 48 F-box.
 DOMAIN 69 250 FBA.
 MOD_RES 268 268 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; DNA damage; DNA repair; Phosphoprotein; Reference proteome; Ubl conjugation pathway; Unfolded protein response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
 GO:0030246; F:carbohydrate binding; IEA:Compara.
 GO:0001948; F:glycoprotein binding; ISS:UniProtKB.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0030433; P:ER-associated protein catabolic process; ISS:UniProtKB.
 GO:0006516; P:glycoprotein catabolic process; IEA:Compara.
 GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. 

Interpro

 IPR007397; F-box-assoc_dom.
 IPR001810; F-box_dom_cyclin-like.
 IPR008979; Galactose-bd-like. 

Pfam

 PF04300; FBA 

SMART

 SM00256; FBOX 

PROSITE

 PS51114; FBA
 PS50181; FBOX 

PRINTS