CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022138
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Copper homeostasis protein cutC homolog 
Protein Synonyms/Alias
  
Gene Name
 CUTC 
Gene Synonyms/Alias
 CGI-32 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
100DREIEVMKADIRLAKubiquitination[1]
186LEGLPLIKRLIEQAKubiquitination[2, 3]
193KRLIEQAKGRIVVMPubiquitination[3]
234STRDSGMKFRNSSVAubiquitination[3]
260LKVTDVTKVRTLNAIubiquitination[4]
269RTLNAIAKNILV***ubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May play a role in copper homeostasis. Can bind one Cu(1+) per subunit. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Copper; Cytoplasm; Metal-binding; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 273 AA 
Protein Sequence
MKRQGASSER KRARIPSGKA GAANGFLMEV CVDSVESAVN AERGGADRIE LCSGLSEGGT 60
TPSMGVLQVV KQSVQIPVFV MIRPRGGDFL YSDREIEVMK ADIRLAKLYG ADGLVFGALT 120
EDGHIDKELC MSLMAICRPL PVTFHRAFDM VHDPMAALET LLTLGFERVL TSGCDSSALE 180
GLPLIKRLIE QAKGRIVVMP GGGITDRNLQ RILEGSGATE FHCSARSTRD SGMKFRNSSV 240
AMGASLSCSE YSLKVTDVTK VRTLNAIAKN ILV 273 
Gene Ontology
 GO:0016235; C:aggresome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005507; F:copper ion binding; IDA:UniProtKB.
 GO:0055070; P:copper ion homeostasis; NAS:UniProtKB.
 GO:0006825; P:copper ion transport; NAS:UniProtKB.
 GO:0051262; P:protein tetramerization; IPI:UniProtKB. 
Interpro
 IPR005627; Cu_homeostasis_CutC.
 IPR023648; Cu_homeostasis_CutC_dom. 
Pfam
 PF03932; CutC 
SMART
  
PROSITE
  
PRINTS