CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014673
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein FAM91A1 
Protein Synonyms/Alias
  
Gene Name
 FAM91A1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
17RHNYPWNKLPANVRQubiquitination[1]
328KSTLDPQKMLLSWDGubiquitination[2, 3]
376SLSTGHTKRIAFLFDubiquitination[2, 3]
426SFLIELEKVQSTGEGubiquitination[2, 3]
559SKGTRLRKLPDIFQSubiquitination[4]
638RVNMGVHKALQILRNubiquitination[1, 4, 5, 6]
815PAKNLIFKDGVLSEWubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 MOD_RES 340 340 Phosphoserine.
 MOD_RES 671 671 Phosphoserine.
 MOD_RES 674 674 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 838 AA 
Protein Sequence
MNIDVEFHIR HNYPWNKLPA NVRQSLGNSQ REYEKQVVLY SIRNQLRYRN NLVKHVKKDE 60
RRYYEELLKY SRDHLMLYPY HLSDIMVKGL RITPFSYYTG IMEDIMNSEK SYDSLPNFTA 120
ADCLRLLGIG RNQYIDLMNQ CRSSKKFFRR KTARDLLPIK PVEIAIEAWW VVQAGYITED 180
DIKICTLPEK CAVDKIIDSG PQLSGSLDYN VVHSLYNKGF IYLDVPISDD SCIAVPPLEG 240
FVMNRVQGDY FETLLYKIFV SIDEHTNVAE LANVLEIDLS LVKNAVSMYC RLGFAHKKGQ 300
VINLDQLHSS WKNVPSVNRL KSTLDPQKML LSWDGGESRS PVQEASSATD TDTNSQEDPA 360
DTASVSSLSL STGHTKRIAF LFDSTLTAFL MMGNLSPNLK SHAVTMFEVG KLSDESLDSF 420
LIELEKVQST GEGEAQRYFD HALTLRNTIL FLRHNKDLVA QTAQPDQPNY GFPLDLLRCE 480
SLLGLDPATC SRVLNKNYTL LVSMAPLTNE IRPVSSCTPQ HIGPAIPEVS SVWFKLYIYH 540
VTGQGPPSLL LSKGTRLRKL PDIFQSYDRL LITSWGHDPG VVPTSNVLTM LNDALTHSAV 600
LIQGHGLHGI GETVHVPFPF DETELQGEFT RVNMGVHKAL QILRNRVDLQ HLCGYVTMLN 660
ASSQLADRKL SDASDERGEP DLASGSDVNG STESFEMVIE EATIDSATKQ TSGATTEADW 720
VPLELCFGIP LFSSELNRKV CRKIAAHGLC RKESLQNLLH SSRKLSLQVL NFVHSFQEGA 780
SILDIHTEPS FSSLLSQSSC ADMGVPLPAK NLIFKDGVLS EWSGRSPSSL LIANLHLQ 838 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS