| Tag | Content |
|---|
| CPLM ID | CPLM-018504 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adenylate cyclase type 4 |
Protein Synonyms/Alias | ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4 |
Gene Name | Adcy4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 549 | IEQLNSQKQWKQSKD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity). |
Sequence Annotation | METAL 278 278 Magnesium 1 (By similarity).
METAL 278 278 Magnesium 2 (By similarity).
METAL 279 279 Magnesium 2; via carbonyl oxygen (By
METAL 322 322 Magnesium 1 (By similarity).
METAL 322 322 Magnesium 2 (By similarity).
CARBOHYD 694 694 N-linked (GlcNAc...) (Potential).
CARBOHYD 701 701 N-linked (GlcNAc...) (Potential). |
Keyword | ATP-binding; cAMP biosynthesis; Complete proteome; Direct protein sequencing; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1077 AA |
Protein Sequence | MARLFSPRPP PSEDLFYETY YSLSQQYPLL ILLLVIVLCA LVALPAVAWA SGRELTSDPS 60
FLTTVLCALG GFSLLLGLAS REQQLQRWTR PLSGLIWVAL LALGYGFLFT GGVVSAWDQV 120
SFFLFIIFTV YAMLPLGMRD AAAAGVISSL SHLLVLGLYL GWQPESQRAL LPQLAANAVL 180
FLCGNVVGAY HKALMERALR ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK 240
AEIMARLQAG QRSRPENTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 300
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR AIRKLRVATG 360
VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME AGGVPGRVHI TGATLALLAG 420
AYAVERADTE HRDPYLRELG EPTYLVIDPR AEEEDEKGTA KGLLSSLEGH TMRPSLLMTR 480
YLESWGAAKP FAHLSHLDSP VSTSTPLPEK AFSPQWSLDR SRTPRGLDDE LDTGDAKFFQ 540
VIEQLNSQKQ WKQSKDFNLL TLYFREKEME KQYRLSALPA FKYYAACTFL VFLSNFTIQM 600
LVTTRPPALI ITYSITFLLF FLLLFVCFSE HLTKCVQKGP KMLHWLPALS VLVATRPGFR 660
VALGTATILL VFTMAIASLL FLPVSSDCLF LASNVSSVTF NASWEMPGSL PLISIPLISI 720
PYSMHCCVLG FLSCSLFLHM SFELKLLLLL LWLVASCSLF LHSHAWLSDC LIARLYQSPS 780
DSRPGVLKEP KLMGAIYFFI FFFTLLVLAR QNEYYCRLDF LWKKKLRQER EETETMENLT 840
RLLLENVLPA HVAPQFIGQN RRNEDLYHQS YECVCVLFAS VPDFKEFYSE SNINHEGLEC 900
LRLLNEIIAD FDELLSKPKF SGVEKIKTIG STYMAATGLN ATSGQDTQQD SERSCSHLGT 960
MVEFAVALGS KLGVINKHSF NNFRLRVGLN HGPVVAGVIG AQKPQYDIWG NTVNVASRME 1020
STGVLGKIQV TEETARALQS LGYTCYSRGS IKVKGKGELC TYFLNTDLTR TGSPSAS 1077 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0030425; C:dendrite; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005622; C:intracellular; IDA:MGI. GO:0005886; C:plasma membrane; TAS:MGI. GO:0004016; F:adenylate cyclase activity; TAS:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0007190; P:activation of adenylate cyclase activity; TAS:MGI. GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IDA:MGI. GO:0035556; P:intracellular signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |