UniProt Accession

 NAGK_HUMAN; Q9UJ70; B4DLZ5; Q53HD5; Q6IA84; Q9BS29; Q9BVP0; Q9NV37 

Genbank Protein ID

 AJ242910; AK001812; AK297224; CR457271; AK222645; AC007881; CH471053; BC001029; BC005371 

Genbank Nucleotide ID

 CAB61848.1; BAA91923.1; BAG59707.1; CAG33552.1; BAD96365.1; AAY14748.1; EAW99780.1; AAH01029.1; AAH05371.1 

Protein Name

 N-acetyl-D-glucosamine kinase 

Protein Synonyms/Alias

 N-acetylglucosamine kinase; GlcNAc kinase 

Gene Name

 NAGK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	HWLIGTDKCVERINE	ubiquitination	[1]
59	MVNRAKRKAGVDPLV	ubiquitination	[1]
219	RFAGFCRKIAEGAQQ	ubiquitination	[1]
237	LSRYIFRKAGEMLGR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity. 

Sequence Annotation

 NP_BIND 6 13 ATP.
 REGION 129 130 Substrate binding.
 REGION 145 147 Substrate binding.
 BINDING 36 36 Substrate.
 BINDING 107 107 Substrate.
 BINDING 152 152 Substrate.
 BINDING 271 271 ATP.
 BINDING 275 275 ATP.
 MOD_RES 76 76 Phosphoserine.
 MOD_RES 205 205 Phosphotyrosine.  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 344 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0045127; F:N-acetylglucosamine kinase activity; IDA:UniProtKB.
 GO:0009384; F:N-acylmannosamine kinase activity; IEA:Compara.
 GO:0006044; P:N-acetylglucosamine metabolic process; TAS:ProtInc.
 GO:0006051; P:N-acetylmannosamine metabolic process; TAS:ProtInc.
 GO:0019262; P:N-acetylneuraminate catabolic process; TAS:UniProtKB. 

Interpro

 IPR002731; ATPase_BadF. 

Pfam

 PF01869; BcrAD_BadFG 

SMART

  

PROSITE

  

PRINTS